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Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson’s disease

  • B. A. Faraj
  • V. M. Camp
  • R. L. Watts
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

The main objective of this study was to determine whether the activation of dopaminergic pathways through adrenal-caudate transplantation stimulates the production of the dopamine cyclic metabolite salsolinol in CSF of patients with Parkinson’s disease. Salsolinol sulfate in CSF samples was assayed by radioenzymatic technique. The outcome of this study revealed that the replacement of degenerative nigrostriatal neurons with new dopamine-producing cells by adrenal brain transplants resulted in significant increase in CSF concentration of salsolinol sulfate as compared to preoperative levels.

Keywords

Caudate Nucleus Adrenal Medulla Dopamine Metabolite Dopamine Deficiency Radioenzymatic Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • B. A. Faraj
    • 1
  • V. M. Camp
    • 1
  • R. L. Watts
    • 1
  1. 1.Departments of Radiology (Division of Nuclear Medicine) and NeurologyEmory University School of MedicineAtlantaUSA

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