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The synaptic noradrenaline concentration in humans as estimated from simultaneous measurements of plasma noradrenaline and dihydroxyphenylglycol (DOPEG)

  • J. Ludwig
  • M. Gerlich
  • T. Halbrügge
  • K.-H. Graefe
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

A linear relationship between plasma DOPEG (ordinate) and plasma noradrenaline (NA; abscissa) was found during orthostasis as well as during NA infusion. The slope of the former (slopeR) was 13 times steeper than that of the latter (slopI). This difference in slopes suggests that the NA concentration in the synaptic cleft is markedly higher than in plasma. The factor (F) characterizing this concentration difference was obtained from F2 = slopeR/slopeI. It amounted to 3.6.

Keywords

Synaptic Cleft Plasma Noradrenaline Arterial Plasma Neuronal Uptake Anaesthetize Rabbit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Eisenhofer G, Goldstein DS, Ropchak TG, Nguyen HQ, Keiser HR, Kopin IJ (1988) Source and physiological significance of plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4-hydroxyphenylglycol alanine in the rat. J Auton Nerv Syst 24:1–14.PubMedCrossRefGoogle Scholar
  2. Goldstein DS, Zimlichmann R, Stull R, Keiser HR, Kopin IJ (1986) Estimation of intrasynaptic norepinephrine concentrations in humans. Hypertension 8:471–475.PubMedGoogle Scholar
  3. Goldstein DS, Eisenhofer G, Stull R, Folio CJ, Keiser HR, Kopin IJ (1988) Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J Clin Invest 81:213–220.PubMedCrossRefGoogle Scholar
  4. Graefe K-H, Henseling M (1983) Neuronal and extraneuronal uptake and metabolism of catecholamines. Gen Pharmacol 14:27–33.PubMedCrossRefGoogle Scholar
  5. Halbrügge T, Wölfel R, Graefe K-H (1989) Plasma 3,4-dihydroxyphenylglycol as a tool to assess the role of neuronal uptake in the anaesthetized rabbit. Naunyn-Schmiedebergs Arch Pharmacol 340:726–732.PubMedGoogle Scholar
  6. Kopin IJ, Zukowska-Grojec Z, Bayorh MA, Goldstein DS (1984) Estimation of intrasynaptic norepinephrine concentrations at vascular neuroeffector junctions in vivo. Naunyn-Schmiedebergs Arch Pharmacol 325:298–305.PubMedCrossRefGoogle Scholar
  7. Kopin IJ (1985) Catecholamine metabolism: basic aspects and clinical significance. Pharmacol Rev 37:333–364.PubMedGoogle Scholar
  8. Ludwig J, Gerhardt T, Haibrügge T, Walter J, Graefe K-H (1988) Plasma concentrations of noradrenaline and 3,4-dihydroxyphenylethyleneglycol under conditions of enhanced sympathetic activity. Eur J Clin Pharmacol 35:261–267.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. Ludwig
    • 1
  • M. Gerlich
    • 1
  • T. Halbrügge
    • 1
  • K.-H. Graefe
    • 1
  1. 1.Medizinische Poliklinik and Institut für PharmakologieUniversity of WürzburgWürzburgFederal Republic of Germany

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