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Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-deprenyl

  • L. Oreland
  • S. S. Jossan
  • P. Hartvig
  • S. M. Aquilonius
  • B. Långström
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

Positron emission tomography (PET) was applied to investigate the rate of turnover of pig brain MAO-B. For this purpose 11 C-L-deprenyl was used as an irreversible ligand, which bind stoichiometrically to the enzyme. A tracer dose of11 C-L-deprenyl was injected and PET scans performed to obtain baseline deprenyl binding. A high dose of unlabelled deprenyl was then administered to inhibit the enzyme and tracer doses of 11 C-L-deprenyl, with subsequent PET analyses, were given at 0, 2, 7, 21 and 42 days. The half-life for the turnover rate calculated was found to be 6.5 days.

Keywords

Positron Emission Tomography Positron Emission Tomography Scan Tracer Dose Brain Monoamine Oxidase Liver Monoamine Oxidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. Oreland
    • 1
  • S. S. Jossan
    • 1
  • P. Hartvig
    • 2
  • S. M. Aquilonius
    • 2
  • B. Långström
    • 3
  1. 1.Department of Medical PharmacologyUniversity of UppsalaUppsalaSweden
  2. 2.University HospitalUniversity of UppsalaUppsalaSweden
  3. 3.Department of Organic ChemistryUniversity of UppsalaUppsalaSweden

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