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The involvement of desipramine-sensitive processes in the extraction of various catecholamines from plasma in the anaesthetized rabbit

  • T. Halbrügge
  • B. Friedgen
  • A. Thyen
  • K.-H. Graefe
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

The effects of desipramine on the total body plasma clearance (Cl) as well as the systemic fractional extraction (ERS) of noradrenaline, dopamine, adrenaline, and isoprenaline, and on the pulmonary fractional extraction (ERp) of dopamine and adrenaline were determined in the anaesthetized rabbit. Under control conditions, noradrenaline, dopamine, adrenaline, and isoprenaline had Cl values of 59.5, 116.2, 68.0, 78.4 (ml kg-1 min-1) and ERS values of 0.709, 0.789, 0.694, 0.669, respectively. The ERp of dopamine was 0.235, while that of adrenaline did not differ from zero. Desipramine reduced the Cl of noradrenaline (by 20%), but did not affect that of the other amines. It also reduced the ERS of noradrenaline (by 31%), dopamine (by 10%) and adrenaline (by 10%); the ERP of dopamine was diminished by 84%.

Keywords

Extraction Ratio Neuronal Uptake Anaesthetize Rabbit Catecholamine Extraction Plasma Catecholamine Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • T. Halbrügge
    • 1
    • 2
  • B. Friedgen
    • 1
  • A. Thyen
    • 1
  • K.-H. Graefe
    • 1
  1. 1.Department of PharmacologyUniversity of WürzburgWürzburgFederal Republic of Germany
  2. 2.Institut für PharmakologieUniversität WürzburgWürzburgFederal Republic of Germany

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