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Molecular neuroanatomy of MAO-A and MAO-B

  • J. Saura Marti
  • R. Kettler
  • M. Da Prada
  • J. G. Richards
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

A selective, quantitative and high resolution technique (in vitro and in vivo enzyme radioautography) has been used to reveal the tissue distribution and abundance of MAO-A and MAO-B in the central nervous system and peripheral organs in the rat. The in vitro approach was also used to map the enzymes in human post-mortem brain. Furthermore, using in situ hybridization histochemistry, locus coeruleus and raphé neurons in the human brain were found to code for MAO-A and MAO-B respectively and not vice versa.

Keywords

Locus Coeruleus Peripheral Organ Bergmann Glia Solitary Tract Nucleus Hybridization Histochemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Da Prada M, Kettler R, Keller HH, Cesura AM, Richards JG, Saura Marti J, Muggli-Maniglio D, Wyss P-C, Kyburz E, Imhof R (1990) From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors. J Neural Transm [Suppl] 29:179–192.Google Scholar
  2. Saura Marti J, Kettler R, Da Prada M, Richards JG (1991) Localization of MAO-A and MAO-B in rat CNS, peripheral organs and human brain: quantitative enzyme radioautography of [3H]Ro 41-1049 and [3H]Ro 19-6327. (Submitted).Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. Saura Marti
    • 1
  • R. Kettler
    • 1
  • M. Da Prada
    • 1
  • J. G. Richards
    • 1
  1. 1.Pharma Research CNSF. Hoffmann-La Roche LtdBaselSwitzerland

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