Mucosal mono- and polyamine oxidase activities in digestive tract are distributed complementary to diamine oxidase

  • W. A. Fogel
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)


The distribution of mucosal monoamine and polyamine oxidases along rat gastrointestinal tract presents a complementary pattern to that of diamine oxidase. The maximal diamine oxidase values are found in the last two thirds of small intestine, whereas the highest activities of monoamine and polyamine oxidase occur in the proximal duodenum and in the large intestine.


Biogenic Amine Amine Oxidase Diamine Oxidase Polyamine Oxidase Proximal Duodenum 
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  1. Baylin SB, Stevens SA, Shakir KMM (1978) Association of diamine oxidase and ornithine decarboxylase with maturing cells in rapidly proliferating epithelia. Biochem Biophys Acta 541:415–419.PubMedCrossRefGoogle Scholar
  2. Beaven MA (1970) Selected topics on the function of biogenic amines in exocrine organs with special reference to histamine in stomach. In: Blum JJ (ed) Biogenic amines as physiological regulators. Prentice-Hall, Englewood Cliffs NJ, pp 207–222.Google Scholar
  3. Beaven MA, Shaff RE (1975) Study of the relationship of histaminase and diamine oxidase activities in various rat tissues and plasma by sensitive isotopic assay procedures. Biochem Pharmacol 24:979–984.PubMedCrossRefGoogle Scholar
  4. Bieganski T (1983) Biochemical, physiological and pathophysiological aspects of intestinal diamine oxidase. Acta Physiol Pol 34:139–154.PubMedGoogle Scholar
  5. Fogel WA, Ulatowska M, Adach K, Osinska Z (1985) A sum of 14C-putrescine metabolites as a measure of DAO activity. Column chromatography assay. Agents Actions 16:99–101.Google Scholar
  6. Hardcastle J, Hardcastle PT (1987) The secretory actions of histamine in rat small intestine. J Physiol 388:521–532.PubMedGoogle Scholar
  7. Kusche J, Lorenz W, Schmidt J (1975) Oxidative deamination of biogenic amines by intestinal amine oxidases: histamine is specifically inactivated by diamine oxidase. Hoppe-Seyler’s Z Physiol Chem 356:1485–1496.PubMedCrossRefGoogle Scholar
  8. Majumdar APN, Johnson LR (1987) Effect of putrescine on oxyntic gland and colonic mucosal growth in rats. Life Sci 41:961–966.PubMedCrossRefGoogle Scholar
  9. Martin JS, Tansy MF (1986) Comparison of the inhibitory effects of spermine, papaverine and adrenaline upon isolated segments of the rat small intestine. Clin Exp Pharmacol Physiol 13:87–90.PubMedCrossRefGoogle Scholar
  10. Matsumoto T, Furuta T, Nimura Y, Suzuki O (1982) Increased sensitivity of the fluorometric method of Snyder and Hendley for oxidase assays. Biochem Pharmacol 31:2207–2209.PubMedCrossRefGoogle Scholar
  11. Rice SL, Eitenmiller RR, Koehler PE (1976) Biologically active amines in food: a review. J Milk Food Technol 39:353–358.Google Scholar
  12. Suzuki O, Matsumoto T, Katsumata Y (1984) Determination of polyamine oxidase activities in human tissues. Experientia 40:838–839.PubMedCrossRefGoogle Scholar
  13. Tutton PJM (1976) The influence of histamine on epithelial cell proliferation in the jejunum of the rat. Clin Exp Pharmacol Physiol 3:369–373.PubMedCrossRefGoogle Scholar
  14. Wurtman RJ, Axelrod J (1963) A sensitive and specific assay for the estimation of monoamine oxidase activity. Biochem Pharmacol 12:1439–1441.PubMedCrossRefGoogle Scholar
  15. Youdim MBH, Finberg JPM (1982) Monoamine oxidase inhibitor antidepressants. In: Grahame-Smith DG, Hippius H, Winokery G (eds) Psychopharmacology. Excerpta Medica, Amsterdam, p 38.Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • W. A. Fogel
    • 1
  1. 1.Department of Biogenic AminesPolish Academy of SciencesLodzPoland

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