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Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells

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Amine Oxidases and Their Impact on Neurobiology

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 32))

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Summary

Metabolism of 5 μM benzylamine (BZ) by rat aortic cultured smooth muscle cells (SMC) is inhibited almost completely by 10-3 M semicarbazide and 10-6 M propargylamine, but is little affected by 10-4 M and 10-3 M pargyline and clorgyline, indicating BZ metabolism predominantly by the semicarbazide-sensitive amine oxidase (SSAO) previously characterized in rat aortic homogenates. Km values of 7–9 μM for BZ metabolism by SSAO in SMC cultures, indicate similar, if not identical properties, to the enzyme in the parent blood vessel.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK

    J. R. D. Blicharski & Dr. G. A. Lyles

Authors
  1. J. R. D. Blicharski
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  2. Dr. G. A. Lyles
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Wurzburg, Federal Republic of Germany

    Peter Riederer

  2. Israel Institute of Technology, Technion, Haifa, Israel

    Moussa B. H. Youdim

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© 1990 Springer-Verlag

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Blicharski, J.R.D., Lyles, G.A. (1990). Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_45

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  • DOI: https://doi.org/10.1007/978-3-7091-9113-2_45

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82239-5

  • Online ISBN: 978-3-7091-9113-2

  • eBook Packages: Springer Book Archive

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