Amine oxidase activities in chemically-induced mammary cancer in the rat
The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(α)anthracene (DMBA).
It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy.
It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.
KeywordsMonoamine Oxidase Benzyl Amine Mammary Cancer Amine Oxidase Oxygen Oxidoreductase
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