Advertisement

Amine oxidase activities in chemically-induced mammary cancer in the rat

  • J. M. Lizcano
  • E. Escrich
  • K. F. Tipton
  • M. Unzeta
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

The activities and distributions of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) were studied in solid breast tumours induced in rat by treatment with 7,12-dimethylbenz(α)anthracene (DMBA).

It was observed that increasing degree of malignancy was associated with an increase of MAO-A activity an decrease of MAO-B and SSAO activities. The Km values did not change significantly with malignancy but Vmax values for MAO-A increased whereas Vmax for MAO-B and SSAO diminished with malignancy.

It was detected in the more malignant tumours the presence of endogenous reversible inhibitor of SSAO activity not removed by dialysis.

Keywords

Monoamine Oxidase Benzyl Amine Mammary Cancer Amine Oxidase Oxygen Oxidoreductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dixon M, Webb EC (1979) Enzymes, 3rd edn. Longman Group, London, pp 48–55.Google Scholar
  2. Fowler CJ, Tipton KF (1981) Concentration dependence of the oxidation of tyramine by the two forms of rat liver mitochondrial monoamine oxidase. Biochem Pharmacol 30:3329–3332.PubMedCrossRefGoogle Scholar
  3. Otsuka S, Kobayashi Y (1964) A radioisotopic assay for manoamine oxidase determination in human plasma. Biochem Pharmacol 13:995–1006.PubMedCrossRefGoogle Scholar
  4. Sunkara PS, Rao PN (1981) The transformed cell. Academic Press, New York, pp 267–291.Google Scholar
  5. Young S, Hallowey RC (1973) In: Turosov VS (ed) Pathology of tumours in laboratory animals, vol 1. Lyon, pp 31-74.Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. M. Lizcano
    • 1
  • E. Escrich
    • 2
  • K. F. Tipton
    • 1
  • M. Unzeta
    • 1
  1. 1.Departament Bioquímica i Biologia MolecularUniversität Autónoma de BarcelonaBellaterra (Barcelona)Spain
  2. 2.Departament Biologia Cellular i Fisiologia, Facultat de MedicinaUniversitat Autónoma de BarcelonaBarcelonaSpain

Personalised recommendations