Monoamine oxidase and oxidative stress at dopaminergic synapses
Increased oxidation of dopamine by monoamine oxidase (MAO) in the striatum is associated with an oxidant stress, expressed as a rise in the level of oxidized glutathione. Oxidation of glutathione is suppressed by MAO inhibitors, such as deprenyl and clorgyline. These observations relate to Parkinson’s disease and to the clinical trial of deprenyl as an agent that may retard progression of the disease.
KeywordsOxidize Glutathione Glutathione Disulfide GSSG Level Peroxidative Stress Nigrostriatal Neuron
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