MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course
In rabbits, 3mg/kg Ro 19-6327 p.o., induced complete monoamine oxidase type B (MAO-B) inhibition in striatum, cerebral cortex, liver and platelets for about 12 h. In healthy human volunteers complete inhibition of platelet MAO was obtained with only 5 mg Ro 19-6327. After 40 and 200 mg Ro 19-6327 the duration of complete MAO-B inhibition was prolonged to 12 and 24 hours, respectively. Changes in brain MAO-B in humans after Ro 19-6327 are likely to be faithfully reflected by platelet MAO activity.
KeywordsFrontal Cortex Blood Platelet Healthy Human Volunteer Rabbit Tissue Monoamine Oxidase Type
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- Da Prada M, Kettler R, Keller HH, Burkard WP (1988) Ro 19-6327, a reversible, highly selective inhibitor of type B monoamine oxidase, completely devoid of tyramine-potentiating effects: comparison with selegiline. In: Sandler M, Dahlström A, Belmaker RH (eds) Progress in catecholamine research, part B. Central aspects. Alan R Liss, New York, pp 359–363.Google Scholar
- Kettler R, Da Prada M (1989) Platelet MAO-B activity in humans and stumptail monkeys: in vivo effects of the reversible MAO-B inhibitor Ro 19-6327. In: Przuntek H, Riederer P (eds) Early diagnosis and preventive therapy in Parkinson’s disease. Springer, Wien New York, pp 213–219.CrossRefGoogle Scholar
- Price GW, Bench CJ, Cremer JC, Luthra SK, Turton DR, Lammertsma AA, Kettler R, Da Prada M, Wood N, Jamieson V, McClelland G, Frackowiak RSJ (1990) Inhibition of human brain monoamine oxidase-B by Ro 19-6327 — in vivo measurement using positron emission tomography. Eur J Pharmacol 183: 166.CrossRefGoogle Scholar