Summary
In rabbits, 3mg/kg Ro 19-6327 p.o., induced complete monoamine oxidase type B (MAO-B) inhibition in striatum, cerebral cortex, liver and platelets for about 12 h. In healthy human volunteers complete inhibition of platelet MAO was obtained with only 5 mg Ro 19-6327. After 40 and 200 mg Ro 19-6327 the duration of complete MAO-B inhibition was prolonged to 12 and 24 hours, respectively. Changes in brain MAO-B in humans after Ro 19-6327 are likely to be faithfully reflected by platelet MAO activity.
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References
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© 1990 Springer-Verlag
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Kettler, R., Cesura, A.M., Dingemanse, J., Da Prada, M. (1990). MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time-course. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_31
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DOI: https://doi.org/10.1007/978-3-7091-9113-2_31
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