Psychometric alterations in treatment with the MAO-A-inhibitor moclobemide

  • W. Classen
  • G. Laux
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)


Two groups of depressed patients were treated either with a selective MAO-A-inhibitor, moclobemide (n = 13) or a tetracyclic antidepressant, maprotiline (n = 18), in a 28 days lasting double blind investigation. Before and after treatment psychopathologic symptoms were rated, motor performance was proven, and acoustic and visual sensomotoric performance were investigated. Deterioration of psychomotor performance were seen in patients without amelioration of their psychopathologic symptoms, especially when treated with moclobemide. These findings were regarded as a hint that possibly the therapeutic agent interacts with the wrong transmitter system and perhaps this is the reason for the deterioration of psychomotor functions.


Depressed Patient Motor Performance Major Depressive Patient Psychomotor Performance Psychomotor Function 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brand N, Jolies J (1987) Information processing in depression and anxiety. Psychol Med 17:145–153.PubMedCrossRefGoogle Scholar
  2. Cohen RM, Weingartner SA, Smallberg A, Pickar D, Murphy DL (1982) Effort and cognition in depression. Arch Gen Psychiatry 39:593–597.PubMedCrossRefGoogle Scholar
  3. Coffey CE (1987) Cerebral laterality and emotion: the neurology of depression. Compr Psychiatry 28:197–219.PubMedCrossRefGoogle Scholar
  4. Posner MI, McLeod P (1982) Information processing models in search of elementary operations. Annu Rev Psychol 33:477.PubMedCrossRefGoogle Scholar
  5. Robertson G, Taylor PJ (1985) Some cognitive correlates of affective disorders. Psychol Med 15:297–309.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • W. Classen
    • 1
  • G. Laux
    • 1
  1. 1.Department of PsychiatryUniversity of WürzburgWürzburgFederal Republic of Germany

Personalised recommendations