Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity

  • P. Celada
  • M. J. Sarrias
  • F. Artigas
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)


We have explored the possibility of using measures of 5-HT (extracellular 5-HT and 5-HIAA in blood) as peripheral indexes of MAO activity. Depressed patients treated with phenelzine for 6 weeks display a dramatic increase of plasma 5-HT (270% of basal values) together with a decrease of plasma 5-HIAA. After treatment with irreversible MAO inhibitors, rat plasma 5-HIAA decreased in a similar fashion than MAO-A activity in liver, lungs and brain, measured using 5-HT as substrate. These results support the use of plasma 5-HT and 5-HIAA in humans to evaluate the action of MAOI on the serotonergic system.


Monoamine Oxidase Inhibitor Peripheral Measure Plasma Serotonin Platelet Monoamine Oxidase Peripheral Index 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • P. Celada
    • 1
  • M. J. Sarrias
    • 1
  • F. Artigas
    • 1
  1. 1.Department of NeurochemistryC.S.I.C.BarcelonaSpain

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