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Effect of selegiline and desmethyl-selegiline on cortical electric activity in rats

  • B. Nickel
  • H. O. Borbe
  • I. Szelenyi
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

The pharmaco-EEG changes caused by the monoamine oxidase (MAO) B inhibitor selegiline were compared with the frequency band alterations aroused by its desmethyl metabolite after oral administration in rats. After single administration (5 mg/kg) the EEG changes caused by selegiline or desmethyl-selegiline differed significantly. Distinct decreases in delta and clear increases in theta EEG frequency bands were obvious after administration of selegiline. The single oral dose of desmethyl-selegiline (5 mg/kg) caused only trendly the same EEG changes observed after giving the mother compound.

Following repeated administration on four consecutive days no significant differences in the frequency band changes could be seen after selegiline or desmethyl-selegiline. Based on present results it is likely that the mode of action of desmethyl-selegiline appears to be similar or identical with the mode of action of the parent compound, selegiline.

Keywords

Monoamine Oxidase Cortical Electric Activity Theta Frequency Band Mother Compound Desmethyl Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • B. Nickel
    • 1
  • H. O. Borbe
    • 1
  • I. Szelenyi
    • 1
  1. 1.Departments of Pharmacology and BiochemistryASTA Pharma AGFrankfurt/MainFederal Republic of Germany

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