Effect of selegiline and desmethyl-selegiline on cortical electric activity in rats

  • B. Nickel
  • H. O. Borbe
  • I. Szelenyi
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)


The pharmaco-EEG changes caused by the monoamine oxidase (MAO) B inhibitor selegiline were compared with the frequency band alterations aroused by its desmethyl metabolite after oral administration in rats. After single administration (5 mg/kg) the EEG changes caused by selegiline or desmethyl-selegiline differed significantly. Distinct decreases in delta and clear increases in theta EEG frequency bands were obvious after administration of selegiline. The single oral dose of desmethyl-selegiline (5 mg/kg) caused only trendly the same EEG changes observed after giving the mother compound.

Following repeated administration on four consecutive days no significant differences in the frequency band changes could be seen after selegiline or desmethyl-selegiline. Based on present results it is likely that the mode of action of desmethyl-selegiline appears to be similar or identical with the mode of action of the parent compound, selegiline.


Monoamine Oxidase Cortical Electric Activity Theta Frequency Band Mother Compound Desmethyl Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Birkmayer W, Riederer P, Youdim MBH, Linauer W (1975) The potentiation of the anti-akinetic effect after L-dopa treatment by an inhibitor of MAO-B, deprenyl. J Neural Transm 36:303–326.PubMedCrossRefGoogle Scholar
  2. Borbe HO, Niebch G, Nickel B (1990) Kinetic evaluation of MAO-B activity following oral administration of selegiline and desmethyl-selegiline in the rat. (in preparation).Google Scholar
  3. Dietsch G (1932) Fourier-Analyse von Elektroencephalogrammen des Menschen. Pflügers Arch Ges Physiol 230:106–112.CrossRefGoogle Scholar
  4. Johnston JP (1968) Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem Pharmacol 17:1285–1297.PubMedCrossRefGoogle Scholar
  5. Knoll J, Magyar K (1972) Some puzzling pharmacological effects of monoamine oxidase inhibitors. In: Costa E, Sandier M (eds) Monoamine oxidase — new vistas. Raven Press, New York, pp 393–408.Google Scholar
  6. Kobal G, Nickel B, Hummel Th, Szelenyi I (1990) Comparison of EEG changes induced by flupirtine in man and rats. Neuropharmacology (in press).Google Scholar
  7. Nickel B, Zerrhan H (1987) Pharmaco-electroencephalography in the rat as a method for characterization of different types of analgesics. Postgrad Med J 63 [Suppl 3]:45–47.PubMedCrossRefGoogle Scholar
  8. Nickel B, Szelenyi I (1989) Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepam. Neuropharmacology 28(8):799–803.PubMedCrossRefGoogle Scholar
  9. Tallarida RJ, Murray RB (1984) Manual of pharmacological calculations with computer programs. Springer, Berlin Heidelberg New York.Google Scholar
  10. Zilles K (1985) The cortex of the rat. Springer, Berlin Heidelberg New York.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • B. Nickel
    • 1
  • H. O. Borbe
    • 1
  • I. Szelenyi
    • 1
  1. 1.Departments of Pharmacology and BiochemistryASTA Pharma AGFrankfurt/MainFederal Republic of Germany

Personalised recommendations