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Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates

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Amine Oxidases and Their Impact on Neurobiology

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 32))

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Summary

Stylbasole analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were studied as monoamine oxidase (MAO) substrates. Dehydrogenation of these compounds was shown to be catalyzed by both serotonine specifical and benzylamine specifical MAO activities. Markedly high affinity of stylbasoles to B type of MAO was found. Influence of substrate structure on its biotransformation effectiveness is realized by the principle — “better binding-worse catalysis”. MAO inactivation during the reaction is appeared to be realized as result of product inhibition and perhaps of substrate inhibition.

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References

  • Bachurin SO, Sablin SO, Grishina GV, Gaydarova EL, Dubova LG, Zubov ND (1989) Monoamine oxidase catalysis of bioconversion of physiologically active 1-methyl-4-aryl-1,2,3,6-tetrahydropyridines. Bioorganicheskaya khimia 15:620–626 (russ).

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Author information

Authors and Affiliations

  1. Institute of Physiologically Active Substances, Academy of Sciences of USSR, Chernogolovka, Moscow Region, 142432, USSR

    S. O. Sablin, Dr. S. O. Bachurin & S. E. Tkachenko

Authors
  1. S. O. Sablin
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  2. Dr. S. O. Bachurin
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  3. S. E. Tkachenko
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Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Wurzburg, Federal Republic of Germany

    Peter Riederer

  2. Israel Institute of Technology, Technion, Haifa, Israel

    Moussa B. H. Youdim

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© 1990 Springer-Verlag

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Sablin, S.O., Bachurin, S.O., Tkachenko, S.E. (1990). Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_16

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  • DOI: https://doi.org/10.1007/978-3-7091-9113-2_16

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82239-5

  • Online ISBN: 978-3-7091-9113-2

  • eBook Packages: Springer Book Archive

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