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Inhibition of MAO by substituted tryptamine analogues

  • Dolors Balsa
  • E. Fernandez-Alvarez
  • K. F. Tipton
  • M. Unzeta
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

Three different acetylenic analogues of tryptamine, in which the side chain is attached at the 2 position of the heterocyclic ring, were studied as inhibitors of MAO-A and MAO-B.

IC50 values were determined after 30 min preincubation of the enzyme and inhibitor, at 37°C before assay. Irreversibility and time-dependence of the inhibiton were also established in each case. The kinetic parameters defining non-covalent complex formation and covalent adduct formation were calculated for the mechanism-based inhibition of both MAO-A and MAO-B by these compounds.

Keywords

Monoamine Oxidase Heterocyclic Ring Acetylenic Group Mitochondrial Monoamine Oxidase Reaction Progress Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Dolors Balsa
    • 1
  • E. Fernandez-Alvarez
    • 2
  • K. F. Tipton
    • 1
  • M. Unzeta
    • 1
  1. 1.Department de Bioquimica i Biología Molecular, Facultat de MedicinaUniversitat Autónoma de BarcelonaBellaterra (Barcelona)Spain
  2. 2.Departmento de Química OrgánicaConsejo Superior de Investigaciones CientíficasMadridSpain

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