Summary
Three different acetylenic analogues of tryptamine, in which the side chain is attached at the 2 position of the heterocyclic ring, were studied as inhibitors of MAO-A and MAO-B.
IC50 values were determined after 30 min preincubation of the enzyme and inhibitor, at 37°C before assay. Irreversibility and time-dependence of the inhibiton were also established in each case. The kinetic parameters defining non-covalent complex formation and covalent adduct formation were calculated for the mechanism-based inhibition of both MAO-A and MAO-B by these compounds.
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References
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© 1990 Springer-Verlag
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Balsa, D., Fernandez-Alvarez, E., Tipton, K.F., Unzeta, M. (1990). Inhibition of MAO by substituted tryptamine analogues. In: Riederer, P., Youdim, M.B.H. (eds) Amine Oxidases and Their Impact on Neurobiology. Journal of Neural Transmission, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9113-2_13
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DOI: https://doi.org/10.1007/978-3-7091-9113-2_13
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82239-5
Online ISBN: 978-3-7091-9113-2
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