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Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propyl-1-aminopentane and N-(2-propylpentyl)glycinamide as valproic acid precursors

  • P. H. Yu
  • B. A. Davis
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 32)

Summary

2-Propyl-1-aminopentane (2-PAP) and N-(2-propylpentyl)glycinamide (PPG) were readily deaminated by rat liver monoamine oxidase B and rat aorta semicarbazide-sensitive amine oxidase. The deaminated product, valproic acid (VPA), was identified by HPLC-fluorometric assessment. Absorption and biotransformation of these compounds and their VPA metabolite into the brain were rapid processes. An investigation was conducted to examine whether these compounds can be used as VPA prodrugs. Both compounds, however, at relatively low doses exhibited distinct tremor effects in mice and rats. They also potentiate the convulsant effect induced by mercaptopropionic acid (MPA).

Keywords

Valproic Acid Anticonvulsant Activity Aliphatic Amine Amine Oxidase Clonic Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • P. H. Yu
    • 1
  • B. A. Davis
    • 1
  1. 1.Neuropsychiatric Research Unit, Department of PsychiatryUniversity of SaskatchewanSaskatoonCanada

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