The Effect of Barbiturate and Mannitol on CBF and Metabolism
Up to this point two principles regarding control of intracranial hypertension (hypothermia and prolonged artificial hyperventilation) have been discussed. The use of Ca + + blocking agents and indomethacin will not be discussed in this review, because at present no clinical studies in patients with severe head injury are available. On the other hand, barbiturate and mannitol have been used in the control of ICP-hypertension for many years. In the following the effects of barbiturate and mannitol on CBF and metabolism are reviewed.
KeywordsIntracranial Hypertension Blood Viscosity Cerebral Autoregulation Severe Head Injury Osmotic Gradient
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