Dopamine beta-hydroxylase and beta 2-microglobulin in cerebrospinal fluid: early markers in Parkinson’s disease?
Dopamine beta-hydroxylase (DBH) activity, DBH protein, and beta 2-microglobulin (B 2-MG), the light chain of the class 1 major histocompatibility complex (MHC), were found to be significantly reduced in cerebrospinal fluid (CSF) from parkinsonian patients. A significantly positive correlation was observed between DBH activity and DBH protein or B 2-MG. The results suggest a probable link between the changes in the immune system and those in the noradrenergic neurons in Parkinson’s disease. It remains to be examined whether DBH or B 2-MG in CSF could be an early marker in Parkinson’s disease.
KeywordsMajor Histocompatibility Complex Tyrosine Hydroxylase Parkinsonian Patient Dipeptidyl Peptidase Human Cerebrospinal Fluid
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