Characterisation of Parkinson’s disease using positron emission tomography
Positron emission tomography (PET) can be applied in the study of the pathophysiology of Parkinson’s disease (PD) and other conditions. An early diagnosis of PD should in principle be possible, since in this condition dopamine turnover is markedly decreased while dopamine D2 receptor-density is generally unimpaired. In other neurodegenerative conditions accompanied by parkinsonism both “pre” and “post-synaptic” binding of tracers seems to be impaired.
In PD the loss of cells within the nigrostriatal pathway seems less outspoken when compared to the severe decrease of endogenous dopamine concentration.
KeywordsPositron Emission Tomography Positron Emission Tomography Tomograph Dopamine Receptor Binding Positron Emission Tomography Group Fluorodopa Uptake
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