The premorbid personality of patients with Parkinson’s disease

  • W. Poewe
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)


Psychoanalysts in the first half of this century have speculated on the pathogenetic role of premorbid suppression of impulse in an introverted personality for later development of Parkinson’s disease. More recent studies seem to support introversion, a predisposition towards depression and mental inflexibility as frequent premorbid personality features of parkinsonians. Neurobehavioural abnormalities found in the early stages of the disease include set-shifting difficulties, cognitive slowing and depression. Premorbid behavioural traits might represent the earliest sign of brain neurochemical dysfunction in Parkinson’s disease.


Cognitive Slowing Premorbid Personality Neuropsychological Abnormality Pulsive Disorder Introverted Personality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Agid Y, Ruberg M, Dubois B, Javoy-Agid F (1984) Biochemical substrates of mental disturbances in Parkinson’s disease. Adv Neurol 40: 211–218PubMedGoogle Scholar
  2. Ajuriaguerra J de (1970) Etude psychopathologiquedes parkinsoniens. In: Ajuriaguerra J de, Gauthier G (eds) Monoamines noyaux gris centraux et syndrome de Parkinson. Masson, Paris, pp 327–351Google Scholar
  3. Bihari K, Lees AJ (1987) Cigarette smoking, Parkinson’s disease and ulcerative colitis. J Neurol Neurosurg Psychiatry 50: 635PubMedCrossRefGoogle Scholar
  4. Calne DB, Langston JW, Martin WRW, Stoessl AJ, Ruth TJ, Adam MJ, Pate BD, Schulzer M (1985) Positron emission tomography after MPTP: observations relating to the cause of Parkinson’s disease. Nature 317: 246–248PubMedCrossRefGoogle Scholar
  5. Camp CD (1913) Paralysis agitans, multiple sclerosis and their treatment. In: White WA, Jeliffe SE (eds) Modern treatment of nervous and mental disease. Henry Kimpton, Philadelphia, pp 651–667CrossRefGoogle Scholar
  6. Canavan AGM, Passingham RE, Marsden CD, Quinn N, Wyke M, Polkey CE (1989) The performance on learning tasks of patients in the early stages of Parkinson’s disease. Neuropsychologia 27: 141–156PubMedCrossRefGoogle Scholar
  7. Cohen-Booth G (1935) Paralysis agitans. Entstehungsbedingungen und Beeinflussungsmöglichkeiten. Nervenarzt 8: 69–83Google Scholar
  8. Gibb WRG (1989) Dementia and Parkinson’s disease. Br J Psychiatry 154: 596–614PubMedCrossRefGoogle Scholar
  9. Godwin-Austen RB, Lee PN, Marmot MG, Stern GM (1982) Smoking and Parkinson’s disease. J Neurol Neurosurg Psychiatry 45: 577–581PubMedCrossRefGoogle Scholar
  10. Golbe LI, Cody RA, Duvoisin RC (1986) Smoking and Parkinson’s disease. Search for a dose-response relationship. Arch Neurol 43: 774–778PubMedCrossRefGoogle Scholar
  11. Hornykiewicz O (1982) Brain neurotransmitter changes in Parkinson’s disease. In: Marsden CD, Fahn S (eds) Movement disorders. Butterworth Scientific, London, pp 41–58Google Scholar
  12. Hansch EC, Syndulko K, Cohen SN, Goldberg ZI, Potvin AR, Tourtellotte WW (1982) Cognition in Parkinson’s disease: an event-related potential perspective. Ann Neurol 11: 599–607PubMedCrossRefGoogle Scholar
  13. Kessler H, Diamond KL (1967) Epidemiological studies of Parkinson’s disease. 1. Smoking and Parkinson’s disease. Am J Epidemiol 94: 16–25Google Scholar
  14. Korten J J, Ketterings K (1972) Anthropologische Aspekte der Parkinson’schen Krankheit. Nervenarzt 43: 201–205PubMedGoogle Scholar
  15. Lees AJ (1989) The neurobehavioural abnormalities in Parkinson’s disease and their relationship to psychomotor retardation and obsessional compulsive disorders. Behav Neurol 2: 1–11Google Scholar
  16. Lees AJ, Smith E (1983) Cognitive deficits in the early stages of Parkinson’s disease. Brain 106: 257–270PubMedCrossRefGoogle Scholar
  17. Mitscherlich M (1960) The psychic state of patients suffering from Parkinsonism. Psychosom Med 1: 317–324Google Scholar
  18. Naville F (1922) Les complications et les séquelles mentales de l’encéphalite épidémique. Encéphale 17: 369–375Google Scholar
  19. Poewe W, Gerstenbrand F, Ransmayr G, Plörer S (1983) Premorbid personality of Parkinson patients. J Neural Transm [Suppl 19]: 215–224Google Scholar
  20. Poewe W, Gerstenbrand F, Karamat E, Schmidhuber-Eiler B (1989) The premorbid personality of patients with Parkinson’s disease. In: Przuntek H, Riederer P (eds) Early diagnosis and preventive therapy in Parkinson’s disease. Springer, Wien New York, pp 1–7Google Scholar
  21. Riklan M, Weiner H, Diller L (1959) Somato-psychologic studies in Parkinson’s disease. 1. An investigation into the relationship of certain disease factors to psychological function. J Nery Ment Dis 129: 263–272CrossRefGoogle Scholar
  22. Royal College of Physicians (1977) Smoking and health. Pitman Medical, LondonGoogle Scholar
  23. Rogers D, Less AJ, Smith E, Trimble M, Stern GM (1987) Bradyphrenia in Parkinson’s disease and psychomotor retardation in depressive illness. Brain 110: 761–776PubMedCrossRefGoogle Scholar
  24. Sands IR (1942) The type of personality susceptible to Parkinson’s disease. J Mt Sinai Hosp 9: 792–794Google Scholar
  25. Snyder SH, D’Amato RJ (1986) MPTP: a neurotoxin relevant to the pathophysiology of Parkinson’s disease. Neurology 36: 250–258PubMedGoogle Scholar
  26. Santamaria J, Tolosa E, Valles A (1986) Parkinson’s disease with depression: a possible subgroup of idiopathic parkinsonism. Neurology 36: 1130–1133PubMedGoogle Scholar
  27. Todes CJ, Lees AJ (1985) The premorbid personality of patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 48: 97–100PubMedCrossRefGoogle Scholar
  28. Taylor AE, Saint-Cyr JA, Lang AE, Kenny FT (1986) Frontal lobe dysfunction in Parkinson’s disease. Brain 109: 845–883PubMedCrossRefGoogle Scholar
  29. Ward CD, Duvoisin RC, Ince SE (1984) Parkinson’s disease in twins. Adv Neurol 40: 341–344PubMedGoogle Scholar
  30. Wilson RS, Kasniak AW, Klawans HL, Garron DC (1980) High speed memory scanning in Parkinsonism. Cortex 16: 67–72PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • W. Poewe
    • 1
  1. 1.Universitätsklinik für NeurologieInnsbruckAustria

Personalised recommendations