Summary
Diagnosis of idiopathic Parkinson’s disease (PD) is essentially clinical and is reached by exclusion. An akinetic rigid syndrome frequently means PD, although a number of other neurodegenerative diseases can share bradykinesia, rigidity, postural instability, and sometimes tremor. Parkinsonism can be classified as follows: pure parkinsonism; parkinsonism associated with other neurological and clinical signs; parkinsonism plus dementia; post-intoxication parkinsonism and parkinsonism due to other causes. The diagnostic approach will be discussed.
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References
Alvord EC (1965) The pathology of parkinsonism: etiologic, pathogenetic and prognostic implications. Trans Am Neurol Assoc 90: 167–168
Boller F, Mizutani R, Roessman U, Gambetti F (1980) Parkinson’s disease, dementia and Alzheimer’s disease: clinicopathological correlations. Ann Neurol 1: 329–335
Brown RG, Marsden CD (1984) How common is dementia in Parkinson’s disease? Lancet 11: 1262–1265
Denny-Brown D (1968) Clinical symptomatology of diseases of the basal ganglia. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 6. Diseases of the basal ganglia. North-Holland, Amsterdam, pp 133–211
Duvoisin RC (1987) The olivopontocerebellar atrophies. In: Marsden CD, Fahn S (eds) Movement disorders, 2nd edn. Butterworths Scientific, London, pp 249–271
Duvoisin RC, Yahr MD (1965) Encephalitis and parkinsonism. Arch Neurol 12: 227–239
Forno LS, Langston JW, Delanney LE, Irwin I, Ricaurte GA (1986) Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol 20: 449–455
Jackson JA, Jankovic J, Ford J (1983) Progressive supranuclear palsy: clinical features and response to treatment in 16 patients. Ann Neurol 13: 273–278
Langston JW, Ballard PA (1983) Parkinson’s disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine ( MPTP ). N Engl J Med 309: 310
Lees AJ (1987) The Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). In: Marsden CD, Fahn S (eds) Movement disorders, 2nd edn. Butterworths Scientific, London, pp 272–287
Marsden CD (1984) Motor disorders in basal ganglia disease. Hum Neurobiol 2: 245–250
Miyasaki K, Fujita T (1977) Parkinsonism following encephalitis of unknown etiology. J Neuropathol Exp Neurol 34: 1–8
Oppenheimer DR (1983) Neuropathology of progressive autonomic failure. In: Bannister R (ed) Autonomic failure. Oxford University Press, New York, pp 267–283
Parkes JD, Marsden CD, Rees JE, Carjon M (1974) Parkinson’s disease, cerebral arteriosclerosis and senile dementia. Q J Med 43: 49–61
Richardson JC, Steele J, Olszewski J (1963) Supranuclear ophthalmoplegia, pseudobulbar palsy, dystonia and dementia. Trans Am Neurol Assoc 88: 25–27
Shy GM, Drager GA (1960) A neurological syndrome associated with orthostatic hypotension. Arch Neurol 2: 511–527
Takei Y, Mirra SS (1973) Striato-nigral degeneration: a form of multiple system atrophy with clinical parkinsonism. Prog Neuropathol 21: 26–32
Von Economo C (1931) Encephalitis lethargica. Its sequelae and treatment. Newman KO (trans!), Oxford University, London
Walshe JM (1976) Wilson’s disease (Hepatolenticular degeneration). In: Vinken PJ, Bruyn GW, Klawans HL (eds) Handbook of clinical neurology, vol 27. Metabolic and deficiency disease of the nervous system, part 1. Elsevier, New York, pp 379–414
Whitehouse P, Hedreen JC, White C, DeLong M, Price DL (1983) Basal forebrain neurons in dementia of Parkinson’s disease. Ann Neurol 13: 243–248
Wilson SAK (1912) Progressive lenticular degeneration. A familial nervous disease associated with cirrhosis of the liver. Brain 34: 295–309
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Agnoli, A., Stocchi, F., Carta, A. (1990). Differential diagnosis of Parkinson’s disease. In: Dostert, P., Riederer, P., Strolin Benedetti, M., Roncucci, R. (eds) Early Markers in Parkinson’s and Alzheimer’s Diseases. New Vistas in Drug Research, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9098-2_3
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DOI: https://doi.org/10.1007/978-3-7091-9098-2_3
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