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The presence of antibrain antibodies in the CSF of some Alzheimer disease patients: correlation with CSF parameters

  • A. McRae
  • K. Blennow
  • A. Wallin
  • P. Fredman
  • C. G. Gottfries
  • A. Dahlström
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)

Summary

Our recent investigations demonstrated that antibodies in the cerebrospinal fluid (CSF) of some AD patients recognize cholinergic neuronal populations in the rat central nervous system (CNS). The present study correlated immunocytochemical markings produced by AD and control CSF samples in a cholinergic brain region with clinical and CSF protein parameters. There was a higher incidence of positive markings produced by AD CSF compared to control CSF. No correlation was noted with basic clinical data. However, the blood-brain barrier function was significantly correlated with immunocytochemical markings produced by AD CSF.

Keywords

Medial Septum Alzheimer Disease Patient Albumin Ratio Basic Clinical Data Immunocytochemical Marking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • A. McRae
    • 1
    • 2
  • K. Blennow
    • 3
  • A. Wallin
    • 3
  • P. Fredman
    • 3
  • C. G. Gottfries
    • 3
  • A. Dahlström
    • 1
  1. 1.Institute of NeurobiologyUniversity of GöteborgGöteborgSweden
  2. 2.U-259BordeauxFrance
  3. 3.St. Jörgens HospitalGöteborgSweden

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