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Enzymes and glial cells in brain damage and neurodegenerative diseases

  • G. J. McBean
  • E. B. Horner
  • I. Couée
  • J. P. Phillips
  • M. O’Brien
  • T. C. Lee
  • K. F. Tipton
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)

Summary

Neurodegenerative diseases may also involve damage to glial cells. An apparent glial cell involvement in the neurotoxicity of kainate is, for example, demonstrated by the protection afforded by D,L-a-aminoadipate at concentrations where it selectively affects glial cells. Immunological determination of the serum levels of creatine kinase-BB can be used to monitor astrocyte damage following head injury and may also be of value in degenerative conditions. The recessive adult-onset form of olivopontocerebellar atrophy has been reported to involve a deficiency of a specific membrane-bound isoenzyme of glutamate dehydrogenase (GDH). However attempts to distinguish this enzyme from the well-studied mitochondrial GDH using polyclonal antibodies were unsuccessful.

Keywords

Creatine Kinase Glutamate Dehydrogenase Brain Damage Thiamine Deficiency Glutamine Synthetase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • G. J. McBean
    • 1
  • E. B. Horner
    • 1
  • I. Couée
    • 1
  • J. P. Phillips
    • 2
  • M. O’Brien
    • 3
  • T. C. Lee
    • 3
  • K. F. Tipton
    • 1
  1. 1.Department of BiochemistryTrinity CollegeDublinIreland
  2. 2.Department of NeurosurgeryBeaumont HospitalDublinIreland
  3. 3.Department of AnatomyTrinity CollegeDublinIreland

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