Reference-free evaluation of auditory evoked potentials-P 300 in aging and dementia

  • T. Dierks
  • K. Maurer
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)


Latency, field range (amplitude), and topography of AEP-P 300 were compared in a young and a geriatric control group vs a group of DAT patients, using reference-independent, spatial-related measurements. Latencies in the geriatric control group were significantly prolonged and field range was diminished in geriatric controls and in the DAT-group as compared to younger controls. The topography changed in DAT-patients.


Demented Patient Field Range Auditory Evoke Potential Brain Electrical Activity Bioi Psychiatry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brown WS, Marsh JT, LaRue A (1983) Exponential electrophysiological aging: P 3 latency. Electroencephalogr Clin Neurophysiol 55: 277–285PubMedCrossRefGoogle Scholar
  2. Brun A, Gustafson L (1976) Distribution of cerebral degeneration in Alzheimer’s disease. Arch Psychiatr Nervenkr 223: 15–33PubMedCrossRefGoogle Scholar
  3. Canter NL, Hallett M, Growdon JH (1982) Lecithin does not affect EEG spectral analysis or P 300 in Alzheimer’s disease. Neurology 32: 1260–1266PubMedGoogle Scholar
  4. Duffy FH, Bartels PH, Burchfiel JL (1981) Significance probability mapping: an aid in the topographic analysis of brain electrical activity. Electroencephalogr Clin Neurophysiol 51: 455–462PubMedCrossRefGoogle Scholar
  5. Duffy FH, Albert MS, McAnulty G, Garvey A J (1984) Age-related differences in brain electrical activity of healthy subjects. Ann Neurol 16: 430–438PubMedCrossRefGoogle Scholar
  6. Duffy FH, Albert MS, McAnulty G (1984) Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type. Ann Neurol 16: 439–448PubMedCrossRefGoogle Scholar
  7. Friedland RP, Budinger TF, Ganz E, Yukio Y, Mathis CA, Koss B, Ober B, Huesman RH, Derenzo SE (1983) Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]-fluorodeoxyglucose. J Comput Assist Tomogr 7 (4): 590–598PubMedCrossRefGoogle Scholar
  8. Goodin DS, Squires KC, Henderson BH, Starr A (1978) Age-related variations in evoked potentials to auditory stimuli in normal human subjects. Electroencephalogr Clin Neurophysiol 44: 447–458PubMedCrossRefGoogle Scholar
  9. Gordon E, Kraiuhin C, Harris A, Meares R, Howson A (1986) The differential diagnosis of dementia using P 300 latency. Biol Psychiatry 21: 1123–1132PubMedCrossRefGoogle Scholar
  10. Halgren E, Stapleton JM, Smith M, Altafullah I (1986) Generators of the human scalp P 3(s). In: Cracco RQ, Bodis Wollner I (eds) Evoked potentials. Alan R Liss, New York, pp 269–284Google Scholar
  11. Jasper HH (1958) Report of committee on methods of clinical examination in electroencephalography. Electroencephalogr Clin Neurophysiol 10: 370–375CrossRefGoogle Scholar
  12. Kahn EM, Weiner RD, Brenner RP, Coppola R (1988) Topographic maps of brain electrical activity—pitfalls and precautions. Biol Psychiatry 23: 628–636PubMedCrossRefGoogle Scholar
  13. Lehmann D, Skrandies W (1980) Reference-free identification of components of checkerboard-evoked multichannel potential fields. Electroencephalogr Clin Neurophysiol 48: 609–621PubMedCrossRefGoogle Scholar
  14. Lehmann D, Skrandies W (1984) Spatial analysis of evoked potentials in man — a review. Prog Neurobiol 23: 227–250PubMedCrossRefGoogle Scholar
  15. Maurer K, Dierks T (1987) Brain-Mapping — topographische Darstellung des EEG and der evozierten Potentiale in Psychiatrie and Neurologie. Z EEG-EMG 18: 4–12Google Scholar
  16. McCarley RW, Torello M, Shenton M, Duffy FH (1986) The topography of P 300 and spectral energy in schizophrenics and normals. In: Shagass et al (eds) Biological psychiatry. Elsevier, pp 389–391Google Scholar
  17. Morstyn R, Duffy FH, McCarley RW (1983) Altered P 300 topography in schizophrenia. Arch Gen Psychiatry 40: 729–734PubMedCrossRefGoogle Scholar
  18. Offner FF (1950) The EEG as potential mapping: the value of the average monopolar reference. Electroencephalogr Clin Neurophysiol 2: 215–216CrossRefGoogle Scholar
  19. Okada YC, Kaufman L, Williamson SJ (1983) The hippocampal formation as a source of the slow endogenous potentials. Electroencephalogr Clin Neurophysiol 55: 417–426PubMedCrossRefGoogle Scholar
  20. Oken BS, Chiappa KH (1986) Statistical issues concerning computerized analysis of brainwave topography. Ann Neurol 19: 493–494PubMedCrossRefGoogle Scholar
  21. Perrault N, Wolfe R, Picton T (1983) Nasopharyngeal recordings of event related potentials. Ann NY Acad Sci 30: 205–211Google Scholar
  22. Pfefferbaum A, Ford JM, Wenegrat B, Roth WT, Kopell BS (1984) Clinical application of the P 3-component of event-related potentials. I. Normal aging. Electroencephalogr Clin Neurophysiol 59: 85–103PubMedCrossRefGoogle Scholar
  23. Pfefferbaum A, Ford JM, Wenegrat B, Roth WT, Kopell BS (1984) Clinical application of the P 3-component of event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 59: 104–124PubMedCrossRefGoogle Scholar
  24. Picton TW, Stuss DT, Champagne SC, Nelson RF (1984) The effects of age on human event-related potentials. Psychophysiology 21: 312–326PubMedCrossRefGoogle Scholar
  25. Polich J, Ehlers CL, Otis S, Mandell AJ, Bloom FE (1986) P300 latency reflects the degree of cognitive decline in dementing illness. Electroencephalogr Clin Neurophysiol 63: 138–144PubMedCrossRefGoogle Scholar
  26. Reisberg B, London E, Ferris SH, Borenstein J, Scheie L, deLeon M (1983) The brief cognitive rating scale: language, motoric and mood, in concomitants in primary degenerative dementia ( PDD ). Psychopharmacol Bull 19: 702–708Google Scholar
  27. Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer’s disease. Am J Psychiatry 14: 1356–1364Google Scholar
  28. Skrandies W (1984) Scalp potential fields evoked by grating stimuli: effects of spatial frequency and orientation. Electroencephalogr Clin Neurophysiol 58: 325–332PubMedCrossRefGoogle Scholar
  29. Squires NK, Squires KC, Hillyard SA (1975) Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol 38: 387–401PubMedCrossRefGoogle Scholar
  30. Syndulko K, Hansch E, Cohen SN (1982) Long latency related potentials in normal aging and dementia. Adv Neurol 32: 279–293PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • T. Dierks
    • 1
  • K. Maurer
    • 1
  1. 1.Department of PsychiatryUniversity of WürzburgFederal Republic of Germany

Personalised recommendations