Differential diagnosis of early Alzheimer’s disease

  • C. G. Gottfries
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)


The concept of Alzheimer type dementia, as used today, does not imply a homogeneous group of dementias. There is no scientific basis for sampling the presenile form, Alzheimer’s disease (AD), with the senile dementia of the Alzheimer type (SDAT). The rare form of AD seems to be fairly homogeneous. SDAT is much more common than AD and is, evidently, a heterogeneous group. The differentiation of the subgroups is made by thorough clinical investigation, brain imaging techniques and analysis of cerebrospinal fluid and blood. Data indicate that AD is a cortical disorder, while SDAT also involves subcortical areas. The differentiation between SDAT and secondary dementias, such as vitamin B 12 deficiency and leukoaraiosis, is difficult. The SDAT group is assumed to include also forms of normal aging with cognitive impairment.


Vascular Dementia Monoamine Metabolite Alzheimer Type Dementia Dementia Disorder Subcortical Dementia 
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Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • C. G. Gottfries
    • 1
  1. 1.Department of Psychiatry and NeurochemistryGothenburg UniversitySweden

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