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Salsolinol and the early detection of Parkinson’s disease

  • P. Dostert
  • M. Strolin Benedetti
  • G. Dordain
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)

Summary

In a previous study, the daily urinary excretion of total (R + S) salsolinol was shown to be significantly lower in de novo parkinsonian patients than in healthy volunteers.

Here, we report on the urinary concentrations and daily urinary excretion of (R)- and (S)-salsolinol in an additional sample of 12 healthy subjects and 9 de novo parkinsonians. The urinary concentrations of both enantiomers of salsolinol were lower than the limit of detection in the urine of the parkinsonians. (R)-Salsolinol was detectable in the urine of 8 healthy subjects, whereas (S)-salsolinol was detectable in the urine of 3 only. Since 1,2-dehydrosalsolinol was present in the urine of parkinsonian patients, it is suggested that salsolinol bioprecursors such as 1,2-dehydrosalsolinol and 1-carboxysalsolinol might be additional markers for the early detection of Parkinson’s disease.

Keywords

Human Urine Urinary Concentration Pyruvic Acid Boronic Acid Parkinsonian Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • P. Dostert
    • 1
  • M. Strolin Benedetti
    • 1
  • G. Dordain
    • 2
  1. 1.Farmitalia Carlo ErbaResearch and Development — Erbamont GroupMilanItaly
  2. 2.Service de NeurologieHôpital NordClermont-FerrandFrance

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