Salsolinol and the early detection of Parkinson’s disease

  • P. Dostert
  • M. Strolin Benedetti
  • G. Dordain
Part of the New Vistas in Drug Research book series (DRUG RESEARCH, volume 1)


In a previous study, the daily urinary excretion of total (R + S) salsolinol was shown to be significantly lower in de novo parkinsonian patients than in healthy volunteers.

Here, we report on the urinary concentrations and daily urinary excretion of (R)- and (S)-salsolinol in an additional sample of 12 healthy subjects and 9 de novo parkinsonians. The urinary concentrations of both enantiomers of salsolinol were lower than the limit of detection in the urine of the parkinsonians. (R)-Salsolinol was detectable in the urine of 8 healthy subjects, whereas (S)-salsolinol was detectable in the urine of 3 only. Since 1,2-dehydrosalsolinol was present in the urine of parkinsonian patients, it is suggested that salsolinol bioprecursors such as 1,2-dehydrosalsolinol and 1-carboxysalsolinol might be additional markers for the early detection of Parkinson’s disease.


Human Urine Urinary Concentration Pyruvic Acid Boronic Acid Parkinsonian Patient 
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Copyright information

© Springer-Verlag/Wien 1990

Authors and Affiliations

  • P. Dostert
    • 1
  • M. Strolin Benedetti
    • 1
  • G. Dordain
    • 2
  1. 1.Farmitalia Carlo ErbaResearch and Development — Erbamont GroupMilanItaly
  2. 2.Service de NeurologieHôpital NordClermont-FerrandFrance

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