Salsolinol and the early detection of Parkinson’s disease
In a previous study, the daily urinary excretion of total (R + S) salsolinol was shown to be significantly lower in de novo parkinsonian patients than in healthy volunteers.
Here, we report on the urinary concentrations and daily urinary excretion of (R)- and (S)-salsolinol in an additional sample of 12 healthy subjects and 9 de novo parkinsonians. The urinary concentrations of both enantiomers of salsolinol were lower than the limit of detection in the urine of the parkinsonians. (R)-Salsolinol was detectable in the urine of 8 healthy subjects, whereas (S)-salsolinol was detectable in the urine of 3 only. Since 1,2-dehydrosalsolinol was present in the urine of parkinsonian patients, it is suggested that salsolinol bioprecursors such as 1,2-dehydrosalsolinol and 1-carboxysalsolinol might be additional markers for the early detection of Parkinson’s disease.
KeywordsHuman Urine Urinary Concentration Pyruvic Acid Boronic Acid Parkinsonian Patient
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