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Association of chronic renal disease, hypertension, and infection with a rat-borne hantavirus

  • Conference paper
Hemorrhagic Fever with Renal Syndrome, Tick- and Mosquito-Borne Viruses

Part of the book series: Archives of Virology Supplementum ((ARCHIVES SUPPL,volume 1))

Summary

We report an association between past infection with an indigenous rat-borne hantavirus and chronic renal disease, hypertension, and cerebrovascular accidents among individuals using the Johns Hopkins Medical Institution from January 1986 through October 1988. A sample population of 1148 patients receiving quantitative total urine protein tests was screened for IgM and IgG antibodies to three different hantaviruses. Fifteen seropositives (1.3%) were found, of which 12 resided in inner city Baltimore in areas where Norway rats infected with a hantavirus had been captured.

Comparisons of clinical histories for the 15 seropositive people and 73 age-sex matched seronegative controls demonstrated significantly higher rates of chronic renal disease (80% vs. 44%), and hypertensive renal disease (70% vs. 9%) among seropositive patients. Nearly all (14/15) seropositive individuals were clinically hypertensive, and they were nearly five times more likely to have suffered cerebrovascular accidents than seronegative persons. Only one acute illness, consistent with rat-borne hantaviral disease, was documented among these 15 seropositive individuals.

These data suggest that infection with rat-borne hantaviruses in inner city populations in the United States is associated with increased occurrence of chronic renal disease and hypertension.

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Author information

Authors and Affiliations

  1. Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, USA

    G. E. Glass & J. E. Childs

  2. Department of Immunology and Infectious Diseases, The Johns Hopkins University School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA

    G. E. Glass

  3. Division of Nephrology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    A. J. Watson

  4. Department of Epidemiology, U.S. Army Medical Research Institute for Infectious Diseases, Frederick, Maryland, USA

    J. W. LeDuc

Authors
  1. G. E. Glass
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  2. J. E. Childs
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  3. A. J. Watson
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  4. J. W. LeDuc
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Editor information

Editors and Affiliations

  1. Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Fort Collins, CO, USA

    C. H. Calisher Ph.D.

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© 1990 Springer-Verlag

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Glass, G.E., Childs, J.E., Watson, A.J., LeDuc, J.W. (1990). Association of chronic renal disease, hypertension, and infection with a rat-borne hantavirus. In: Calisher, C.H. (eds) Hemorrhagic Fever with Renal Syndrome, Tick- and Mosquito-Borne Viruses. Archives of Virology Supplementum, vol 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9091-3_9

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  • DOI: https://doi.org/10.1007/978-3-7091-9091-3_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82217-3

  • Online ISBN: 978-3-7091-9091-3

  • eBook Packages: Springer Book Archive

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