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Hemorrhagic fever with renal syndrome in Bulgaria: isolation of hantaviruses and epidemiologic considerations

  • S. Vasilenko
  • Irina Brodvarova
  • Yasen Topov
  • L. Shindarov
  • G. Kebedzhiev
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 1)

Summary

Epidemiological analysis of the incidence of hemorrhagic fever with renal syndrome, 1953–1988, showed that this infection is prevalent in many areas of Bulgaria. We developed a method ensuring 100% etiological diagnosis of the diseases by using albino mice for virus isolation and preparation of antigens for serological studies using a complement-fixation test. Experimental infection with hantaviruses was produced in newborn white mice. In these hosts, lesions were mostly observed in the brain, with considerable accumulation of virus detectable by electron microscopic and fluorescent antibody techniques. The virus of hemorrhagic fever with renal syndrome was successfully adapted to cell culture, in which it produced distinct cytopathic effects.

Keywords

Bank Vole Hemorrhagic Fever With Renal Syndrome Viral Encephalitis Natural Focus Dilate Blood Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Vasilenko
    • 1
    • 2
  • Irina Brodvarova
    • 1
  • Yasen Topov
    • 1
  • L. Shindarov
    • 1
  • G. Kebedzhiev
    • 1
  1. 1.Institute of Communicable and Parasitic DiseasesMedical AcademySofiaBulgaria
  2. 2.Institute of Communicable and Parasitic DiseasesMedical AcademySofiaBulgaria

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