Pathogenesis of hemorrhagic fever with renal syndrome virus infection and mode of horizontal transmission of hantavirus in bank voles
Inapparent, persisting hantavirus infection was demonstrated in bank voles (Clethrionomys glareolus) after experimental infection with strain Kazan 6 C.g. isolated in the U.S.S.R. Virus, viral antigen, antibodies, and the capacity for horizontal transmission of infection were demonstrable throughout the period of observation (13 months), the highest titers being observed 10–20 days postinfection. Direct correlation was detected between the intensity of horizontal transmission and the level of humoral immunity. The progeny of infected females were shown to be passively immune for 30–45 days after birth and to be relatively resistant to infection with strain Kazan 6 C.g. during that period.
KeywordsVirus Antigen Bank Vole Horizontal Transmission Hemorrhagic Fever With Renal Syndrome Infected Female
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