Rapid serodiagnosis of hantavirus infections using high density particle agglutination

  • Tetsuo Tomiyama
  • H. W. Lee
Conference paper
Part of the Archives of Virology Supplementum book series (ARCHIVES SUPPL, volume 1)


Antibody against hantaviruses was measured within forty minutes by a passive agglutination procedure using high density composite particles coated with purified Hantaan virus antigen. Antigen for the reaction was prepared from the brains of suckling rats infected with Hantaan virus, using ultracentrifugation, protamine and ethyl alcohol treatment. This method is more sensitive than the immunofluorescent antibody technique and the antigen reacted with antibodies to Hantaan, Seoul and Puumala viruses.


Hemorrhagic Fever With Renal Syndrome Rift Valley Fever Hantavirus Infection Nephropathia Epidemica Hantaan Virus 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Tetsuo Tomiyama
    • 1
  • H. W. Lee
    • 2
  1. 1.Laboratory of Microbiology and ImmunologyUniversity of Tokyo Branch HospitalBunkyo-ku, Tokyo 112Japan
  2. 2.The Institute for Viral DiseasesKorea UniversitySeoulKorea

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