Rapid serodiagnosis of hantavirus infections using high density particle agglutination
Antibody against hantaviruses was measured within forty minutes by a passive agglutination procedure using high density composite particles coated with purified Hantaan virus antigen. Antigen for the reaction was prepared from the brains of suckling rats infected with Hantaan virus, using ultracentrifugation, protamine and ethyl alcohol treatment. This method is more sensitive than the immunofluorescent antibody technique and the antigen reacted with antibodies to Hantaan, Seoul and Puumala viruses.
KeywordsHemorrhagic Fever With Renal Syndrome Rift Valley Fever Hantavirus Infection Nephropathia Epidemica Hantaan Virus
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