Clinical Syndromes of the Hypothalamus
In 1929 Harvey Cushing defined the significance of the hypothalamus as follows: “Here in this well concealed spot almost all to be covered with a thumb-nail lays the very mainspring of primitive existence—vegetative, emotional, reproductive, on which with more or less success man has come to superimpose a cortex of inhibitions” (Cushing 1929). However it was Fröhlich who published the first hypothalamic syndrome in 1901 (Fröhlich 1901). Retrospectively his case appears to have been that of a cystic and haemorrhagic craniopharyngioma. Decades of research and late experience with hypothalamic hormones, developements of thin collimation computerized tomography (CT) and modern neurosurgical techniques in and around the hypothalamus have opened new doors. In 1983 clinicians and experts in basic research met in Munich to discuss modern knowledge of “clinical aspects of the hypothalamus” (Fahlbusch and Schrell 1985).
KeywordsDiabetes Insipidus Insulin Induce Hypoglycaemia Hypothalamic Region Diencephalic Syndrome Hypothalamic Syndrome
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- Carmel PW (1985) Tumours of the third ventricle. Acta Neurochir (Wien)75: 136–146Google Scholar
- Cushing H (1929) The pituitary and hypothalamus. Charles C Thomas, Springfield, IllGoogle Scholar
- Fahlbusch R Buchfelder M Schrell U (1986) Endocrinological disturbances detected in hypothalamic lesions. In: Samii M (ed) Surgery in and around the brain stem and the third ventricle. Springer, Berlin Heidelberg New York, pp 367–374Google Scholar
- Fahlbusch R Buchfelder M Müller OA (1986) Transsphenoidal surgery for Cushing’s disease. J Roy Soc Med 79: 262–269Google Scholar
- Fröhlich A (1901) Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wien Klin Rundschau 15: 883–906Google Scholar
- Lightman SL, Everitt BJ (1986) Water excretion. In: Lightmann SL, Everitt DJ (eds) Neuroendocrinology. Blackwell, Oxford, pp 197–206Google Scholar
- Penfield W (1929) Diencephalic autonomic epilepsy. Arch Neurol Psychiat 22: 358–364Google Scholar
- Russell A (1951) A diencephalic syndrome emaciation in infancy and childhood. Arch Dis Child 26: 275Google Scholar
- Scherbaum WA, Schrell U, Glück M, Fahlbusch R, Pfeiffer EF (1987) Autoantibodies to pituitary corticotropin-producing cells: Possible marker for unfavourable outcome after pituitary microsurgery for Cushing’s disease. Lancet i: 1394–1398Google Scholar
- Stalla GK, Bost H, Kaliebe T, Huber M, Stalla J, Pfeiffer D, Werder K von, Müller OA (1986) Human placental corticotropin releasing factor is identical to hypothalamic corticotropin releasing factor. Acta Endocrin (Kbh) 111 [Suppl 274]: 194Google Scholar
- Werder K von, Losa M, Müller OA, Schweiberer L, Fahlbusch R, Del Pozo E (1984) Treatment of metastasing GRF-producing tumour with a long acting somatostatin analogue. Lancet ii: 282–283Google Scholar