A Clinical Update on Hypothalamic-Pituitary Control

  • M. D. Page
  • J. Webster
  • C. Dieguez
  • R. Hall
  • M. F. Scanlon
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 47)


Over the last three decades major advances in the understanding of hypothalamic-pituitary control mechanisms have led to important diagnostic and therapeutic developments. The early work of Geoffrey Harris, which established the concept of hypothalamic-pituitary control via the microvascular portal system was confirmed by the isolation by Guillemin and Schally in the late 1960’s and early 1970’s, of a variety of chemical mediators of these actions, the hypothalamic regulatory peptides. In more recent times the two most elusive hypothalamic regulatory peptides, corticotrophin releasing factor and growth hormone releasing factor (Table 1) have been isolated and characterised through the efforts of Vale and Guillemin. In this brief review we outline some of the more recent developments which have led to improvements in clinical management of the various endocrine conditions associated with disturbances of specific anterior pituitary hormones.


Pituitary Adenoma Thyroid Stimulate Hormone Growth Hormone Response Growth Hormone Release Anterior Pituitary Cell 


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. D. Page
    • 1
  • J. Webster
    • 1
  • C. Dieguez
    • 1
  • R. Hall
    • 1
  • M. F. Scanlon
    • 1
  1. 1.Neuroendocrine Unit, Department of MedicineUniversity of Wales College of MedicineCardiffWales

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