Abstract
Why are there tens of chemical messengers, when just two—one stimulatory the other inhibitory—would suffice for communication between the many different types of neuron, that act as mediators of the unique signal—the action potential? A naive question with a naive answer: there are several messengers because there are several types of message to be delivered. These latter aren’t limited simply to the opening of ionic channels gathered in a small area of the neuronal membrane to produce a localised depolarisation or hyperpolarization (excitatory or inhibitory post-synaptic potentials), but consist of complex modifications bearing on the whole cell thanks to the intervention of an intracellular second messenger.
And the Lord said, “Behold, they are one people and they have all one language” ... Therefore its name was called Babel because there the Lord confused the language of all the earth and from there the Lord scattered them abroad over the face of all the earth.
Genesis
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Vincent, J.D., Simonnet, G. (1990). Neurohormonal Communication in the Brain. In: Pickard, J.D., Cohadon, F., Antunes, J.L. (eds) Neuroendocrinological Aspects of Neurosurgery. Acta Neurochirurgica, vol 47. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9062-3_2
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