Abstract
In 1981 Marcus Raichle put forward the hypothesis that a central neuroendocrine system regulates the brain ion and water homeostasis38. In this presentation I would like to summarize briefly the available data—including our own results—in support of this hypothesis. The hypothesis supposes that three cell groups (brain capillary endothelial cells, secretory cells of the choroid plexus, and astroglia) regulate the internal ionic environment of the brain38. A unique element of this hypothesis is that the regulation of the ion and volume homeostasis of the brain is orchestrated by a central neuroendocrine system capable of affecting all three cell types38.
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Dóczi, T., Joó, F., Bodosi, M. (1990). Central Neuroendocrine Control of the Brain Water, Electrolyte, and Volume Homeostasis. In: Pickard, J.D., Cohadon, F., Antunes, J.L. (eds) Neuroendocrinological Aspects of Neurosurgery. Acta Neurochirurgica, vol 47. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9062-3_16
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