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Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate

  • L. S. Wolfe
  • L. Pellerin
  • C. Drapeau
  • K. Rostworowski
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)

Summary

The 12-lipoxygenase pathway of arachidonic acid metabolism in rat cerebral cortex slices is stimulated by exogenous arachidonic acid, Ca2+ ionophore A23187, phorbol ester, glutamate, N-methyl-D-aspartate (NMDA) but not by kainate and other neurotransmitters except norepinephrine. The 12-hydroxyeicosatetraenoic acid formed is the (S)-enantiomer. A specific role for 12-lipoxygenase metabolites in NMDA receptor activation and long term potentiation is proposed.

Keywords

High Performance Liquid Chromatography Arachidonic Acid Calcium Ionophore Arachidonic Acid Metabolism FMRF Amide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. S. Wolfe
    • 1
  • L. Pellerin
    • 1
  • C. Drapeau
    • 1
  • K. Rostworowski
    • 1
  1. 1.Donner Laboratory of Experimental Neurochemistry, Montreal Neurological InstituteMcGill UniversityMontrealCanada

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