Formation of 12-lipoxygenase metabolites in rat cerebral cortical slices: stimulation by calcium ionophore, glutamate and N-methyl-D-aspartate

  • L. S. Wolfe
  • L. Pellerin
  • C. Drapeau
  • K. Rostworowski
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)


The 12-lipoxygenase pathway of arachidonic acid metabolism in rat cerebral cortex slices is stimulated by exogenous arachidonic acid, Ca2+ ionophore A23187, phorbol ester, glutamate, N-methyl-D-aspartate (NMDA) but not by kainate and other neurotransmitters except norepinephrine. The 12-hydroxyeicosatetraenoic acid formed is the (S)-enantiomer. A specific role for 12-lipoxygenase metabolites in NMDA receptor activation and long term potentiation is proposed.


High Performance Liquid Chromatography Arachidonic Acid Calcium Ionophore Arachidonic Acid Metabolism FMRF Amide 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. S. Wolfe
    • 1
  • L. Pellerin
    • 1
  • C. Drapeau
    • 1
  • K. Rostworowski
    • 1
  1. 1.Donner Laboratory of Experimental Neurochemistry, Montreal Neurological InstituteMcGill UniversityMontrealCanada

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