The effects of aging on MAO activity and amino acid levels in rat brain

  • M. Strolin Benedetti
  • M. Cini
  • R. Fusi
  • P. Marrari
  • P. Dostert
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)


The possibility that age-related changes in amino acid levels in various rat brain areas might correlate with modifications of monoamine oxidase (MAO) activity, already found with aging, has been examined.

Taurine, aspartic acid and glutamic acid levels were found to be unchanged or decreased with age, whereas GABA and glutamine concentrations increased or remained unchanged. Serine and glycine (except in pons-medulla) levels were found to be unaffected by age. The increase in total MAO activity with aging in some brain areas might contribute to the changes in amino acid levels. Likewise, the possible influence of age-induced changes in activity of various enzymes involved in H2O2 and NH3 detoxication and in amino acid biosynthesis on rat brain amino acid levels are considered. Oral administration of clorgyline or 1-deprenyl to young rats did not significantly modify the concentrations of most brain amino acids.


Hepatic Encephalopathy Amino Acid Level Glutamine Synthetase Activity Brain Ammonia Taurine Chloramine 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. Strolin Benedetti
    • 1
  • M. Cini
    • 1
  • R. Fusi
    • 1
  • P. Marrari
    • 1
  • P. Dostert
    • 1
    • 2
  1. 1.Farmitalia Carlo Erba, R&D—Erbamont GroupMilanItaly
  2. 2.Farmitalia Carlo Erba, Research and DevelopmentMilanItaly

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