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Implantable microencapsulated dopamine (DA): prolonged functional release of DA in denervated striatal tissue

  • Amanda McRae
  • S. Hjorth
  • D. Mason
  • L. Dillon
  • T. Tice
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)

Summary

Biodegradable controlled-release microcapsule systems made with the biocompatible biodegradable polyester excipient poly [DL-lactide-co-gly-colide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microcapsules encapsulated within two different polymer excipients into denervated striatal tissue assures a prolonged release of the transmitter in vivo. This technology has a considerable potential for basic and possibly clinical research.

Keywords

Dorsal Striatum Prolonged Release Central Nervous System Tissue Rotational Behavior Striatal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Amanda McRae
    • 1
    • 2
    • 5
  • S. Hjorth
    • 3
  • D. Mason
    • 4
  • L. Dillon
    • 4
  • T. Tice
    • 4
  1. 1.INSERM U-259BordeauxFrance
  2. 2.Department of HistologyUniversity of GöteborgGöteborgSweden
  3. 3.Department of PharmacologyUniversity of GöteborgGöteborgSweden
  4. 4.Controlled Release DivisionSouthern Research InstituteBirminghamUSA
  5. 5.Institute of NeurobiologyUniversity of GöteborgGöteborgSweden

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