Implantable microencapsulated dopamine (DA): prolonged functional release of DA in denervated striatal tissue

  • Amanda McRae
  • S. Hjorth
  • D. Mason
  • L. Dillon
  • T. Tice
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)


Biodegradable controlled-release microcapsule systems made with the biocompatible biodegradable polyester excipient poly [DL-lactide-co-gly-colide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microcapsules encapsulated within two different polymer excipients into denervated striatal tissue assures a prolonged release of the transmitter in vivo. This technology has a considerable potential for basic and possibly clinical research.


Dorsal Striatum Prolonged Release Central Nervous System Tissue Rotational Behavior Striatal Tissue 
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  1. Arnt J, Bogese KP, Christensen AY, Hytell J, Larsen JJ, Svendsen O (1983) Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers. Psychopharmacology 81: 199–208.PubMedCrossRefGoogle Scholar
  2. Bjorklund A, Lindvall O, Isaacson O, Brundin P, Wictorin K, Strecker R, Clarke D, Dunnett S (1987) Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum. Trends Neurosci 10: 509–516.CrossRefGoogle Scholar
  3. Clark D, Hjorth S, Carlsson A (1985) Dopamine-receptor agonists: mechanisms underlying autoreceptor selectivity. II. Theoretical considerations. J Neural Transm 62: 171–207.PubMedCrossRefGoogle Scholar
  4. Dunnett SB, Bjorklund A, Schmidt RH, Stenevi U, Iverson SD (1983) Behavioral recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different brain sites. Acta Physiol Scand [Suppl 522]: 29-37.Google Scholar
  5. Gauthier S, Leblanc R, Quiron R, Carlsson G, Beaulieu M, Bouchard R, Dastoor D, Ervin F, Gauthier L, Gauvin M, Henry J, Palmour R, Robitaille Y (1986) Transmitter-replacement therapy in Alzheimer’s disease using intracerebroventricular infusions of receptor agonists. Can J Neurol Sci 13: 394–402.PubMedGoogle Scholar
  6. Herrera-Marschitz M, Ungerstedt U (1984) Evidence that apomorphine and pergolide induce rotation in rats by different actions on D1 and D 2 receptor sites. Eur J Pharmacol 98: 165–176.PubMedCrossRefGoogle Scholar
  7. Hjorth S, Carlsson A, Clark D, Svensson K, Wilkström H, Sanchez D, Lindberg P, Hacksell U, Arvidsson LE, Johansson A, Nilsson JLG (1983) Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP. Psychopharmacology 81: 89–99.PubMedCrossRefGoogle Scholar
  8. Joyce JN, Loeschen SK, Marshall JF (1985) Dopamine D-2 receptors in rat caudate— putamen the lateral to median gradient does not correspond to dopaminergic innervation. Brain Res 338: 209–218.PubMedCrossRefGoogle Scholar
  9. Madrazo I, Drucker-Colin R, Diaz V, Martinez-Mata J, Torres C, Becerril JJ (1987) Open microsurgical autograft of adrenal medulla to the right caidate nucleus in 2 patients with intractable Parkinson’s disease. N Engl J Med 316: 831–834.PubMedCrossRefGoogle Scholar
  10. McRae-Degueurce A, Hjorth S, Dillon L, Mason D, Tice T (1988) Implantable microen-capsulated dopamine (DA): a new approach for slow-release DA delivery into brain tissue. Neurosci Lett 92: 303–309.PubMedCrossRefGoogle Scholar
  11. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, New York.Google Scholar
  12. Stromberg I, Herrera-Marschitz M, Ungerstedt U, Ebendal T, Olson L (1985) Chronic implants of chromaffm tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp Brain Res 60: 335–349.PubMedCrossRefGoogle Scholar
  13. Tice T, Cowsar D (1984) Biodegradable controlled-release parenteral systems. Pharm Tech-nol 11: 26–35.Google Scholar
  14. Ungerstedt U (1971) Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand [Suppl] 367: 69–73.Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Amanda McRae
    • 1
    • 2
    • 5
  • S. Hjorth
    • 3
  • D. Mason
    • 4
  • L. Dillon
    • 4
  • T. Tice
    • 4
  1. 1.INSERM U-259BordeauxFrance
  2. 2.Department of HistologyUniversity of GöteborgGöteborgSweden
  3. 3.Department of PharmacologyUniversity of GöteborgGöteborgSweden
  4. 4.Controlled Release DivisionSouthern Research InstituteBirminghamUSA
  5. 5.Institute of NeurobiologyUniversity of GöteborgGöteborgSweden

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