Respective contributions of neuronal activity and presynaptic mechanisms in the control of the in vivo release of dopamine

  • A. Chéramy
  • L. Barbeito
  • G. Godeheu
  • J. M. Desce
  • A. Pittaluga
  • T. Galli
  • F. Artaud
  • J. Glowinski
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)


Studies performed in several in vivo and in vitro conditions have demonstrated that the release of dopamine from nerve terminals of the nigro-striatal dopaminergic neurons depends not only on the activity of dopaminergic cells but also on presynaptic regulations by heterologous fibers. The presynaptic facilitation of dopamine release by the cortico-striatal glutamatergic neurons has been particularly investigated. A quisqualate/kainate receptor subtype is involved in the direct (tetrodotoxine-resistant) presynaptic regulation of dopamine release by glutamate. The respective roles of presynaptic events and nerve activity in the control of dopaminergic transmission are discussed.


Substantia Nigra Dopaminergic Neuron Caudate Nucleus Dopamine Release Dopaminergic Cell 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • A. Chéramy
    • 1
    • 2
  • L. Barbeito
    • 1
  • G. Godeheu
    • 1
  • J. M. Desce
    • 1
  • A. Pittaluga
    • 1
  • T. Galli
    • 1
  • F. Artaud
    • 1
  • J. Glowinski
    • 1
  1. 1.INSERM U114Collège de FranceParisFrance
  2. 2.INSERM U114Collège de FranceParis Cedex 05France

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