Effect of some peptides on dopaminergic function in man

  • S. Lal
  • N. P. V. Nair
  • I. Isaac
  • J. Thavundayil
  • H. Guyda
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)


Thyrotropin-releasing hormone (TRH) (200 μg iv) and 1-desamino-8-D-arginine vasopressin (DDAVP) (4 μg iv) antagonized the growth hormone (GH) response to apomorphine HC1 (Apo) (0.5 mg sc) in 10 normal men. Apo had no effect on basal prolactin (PRL) levels but antagonized the PRL response to TRH. DDAVP plus Apo decreased PRL compared to placebo or DDAVP alone. These observations are compatible with (a) an inhibitory effect of TRH on hypothalamic and pituitary lactotrophe dopamine (DA) function (b) a fa-cilitory effect of DDAVP on lactotrophe DA function and an inhibitory effect on hypothalamic DA function. Whether these are direct or indirect effects on DA mechanisms is unclear.


Growth Hormone Growth Hormone Secretion Growth Hormone Response BioI Psychiatry Basal Prolactin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Lal
    • 1
    • 2
    • 4
  • N. P. V. Nair
    • 1
  • I. Isaac
    • 1
  • J. Thavundayil
    • 1
  • H. Guyda
    • 3
  1. 1.Douglas Hospital Research CentreVerdunCanada
  2. 2.Department of PsychiatryMontreal General HospitalVerdunCanada
  3. 3.Protein and Polypeptide LaboratoryVerdunCanada
  4. 4.Douglas Hospital Research CentreVerdunCanada

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