Histamine inactivation in the brain: aspects of N-methylation
This report deals with molecular and anatomical site of histamine N-methylation assumed to be the exclusive route of HA inactivation. The methyl transfer from the —S—CH3 of S-adenosyl-L-methionine to the ring (tele)-nitrogen of histamine, appears as much more complex than a one-step transformation. It seems that —S—CH3 is transformed before being transferred to the nitrogen of the acceptor probably via methanol (formaldehyde) formation.
For localizations of transmethylation of neuronal histamine we assume at least a two-compartment model in which glia participate to a significant extent. The uptake of neuronal HA into glial cells might be the first step of histamine inactivation.
KeywordsGlial Cell Glutamine Synthetase Activity Histidine Decarboxylase Brain Histamine Histamine Metabolism
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