Inborn errors of carnosine and homocarnosine metabolism

  • L. R. Gjessing
  • H. A. Lunde
  • L. MØrkrid
  • J. F. Lenney
  • O. Sjaastad
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 29)


Serum carnosinase deficiency with carnosinuria has been reported in 23 children with neurological signs and/or mental retardation. In adults four cases in one family had serum carnosinase deficiency, carnosinuria, and in addition elevated homocarnosine in CSF and in the brain. The mother was one of these cases but had no clinical symptoms; however her three children have spastic paraparesis, retinitis pigmentosa and mental retardation. Serum carnosinase deficiency alone is not the cause of the neurological symptoms. When two of the affected children consumed carnosine, anserine or homocarnosine, they metabolized these compounds much less rapidly than did two normal control individuals.


Retinitis Pigmentosa Inborn Error Retinal Pigmentation Urea Cycle Defect Normal Control Individual 
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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • L. R. Gjessing
    • 1
    • 4
  • H. A. Lunde
    • 1
  • L. MØrkrid
    • 1
  • J. F. Lenney
    • 2
  • O. Sjaastad
    • 3
  1. 1.Neurochemical Research Laboratory, Institute of NeuropsychiatryDikemark Hospital, Asker, SolbergNorway
  2. 2.Department of Pharmacology, School of MedicineUniversity of HawaiiHonoluluUSA
  3. 3.Department of NeurologyTrondheim University HospitalTrondheimNorway
  4. 4.Neurochemical Research Laboratory, Institute of NeuropsychiatryDikemark Hospital, AskerSolbergNorway

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