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Indole Alkaloid Production in Catharanthus roseus Cell Suspension Cultures

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Part of the Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products book series (FORTCHEMIE (closed),volume 55)

Abstract

Catharanthus roseus (L.) G. Don, Madagascan periwinkle, is a well-known medicinal herb on which a lot of research has been done, especially on isolation and conversion of its alkaloids. To date more than 100 indole alkaloids have been isolated from the different parts of the plant, many of them with important pharmacological activity (13). The most notable of these therapeutic alkaloids are the antileukemic drugs vinblastine (1) and vincristine (2), the antihypertensive ajmalicine (3) used in combination with reserpine, and serpentine (4) which has a sedative effect. The generally low concentration of these products in a plant which is itself scarce, combined with the difficulty of separating the valuable alkaloids from others co-occurring ones, has encouraged intensive research on their synthesis or semisynthesis (411). So far, however, attempts to produce these alkaloids economically by the normal methods of synthetic organic chemistry have not given satisfactory results.

Keywords

  • Cell Suspension Culture
  • Indole Alkaloid
  • Alkaloid Production
  • Catharanthus Roseus
  • Plant Cell Report

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Lounasmaa, M., Galambos, J. (1989). Indole Alkaloid Production in Catharanthus roseus Cell Suspension Cultures. In: Herz, W., Grisebach, H., Kirby, G.W., Tamm, C. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 55. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9002-9_3

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