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Indole Alkaloid Production in Catharanthus roseus Cell Suspension Cultures

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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Abstract

Catharanthus roseus (L.) G. Don, Madagascan periwinkle, is a well-known medicinal herb on which a lot of research has been done, especially on isolation and conversion of its alkaloids. To date more than 100 indole alkaloids have been isolated from the different parts of the plant, many of them with important pharmacological activity (1–3). The most notable of these therapeutic alkaloids are the antileukemic drugs vinblastine (1) and vincristine (2), the antihypertensive ajmalicine (3) used in combination with reserpine, and serpentine (4) which has a sedative effect. The generally low concentration of these products in a plant which is itself scarce, combined with the difficulty of separating the valuable alkaloids from others co-occurring ones, has encouraged intensive research on their synthesis or semisynthesis (4–11). So far, however, attempts to produce these alkaloids economically by the normal methods of synthetic organic chemistry have not given satisfactory results.

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  1. J. Galambos

    Present address: Gedeon Richter Ltd, Budapest, Hungary

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  1. Laboratory for Organic and Bioorganic Chemistry, Technical University of Helsinki, Finland

    M. Lounasmaa & J. Galambos

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Editors and Affiliations

  1. Department of Chemistry, The Florida State University, Tallahassee, Florida, USA

    W. Herz (Professor of Chemistry) (Professor of Chemistry)

  2. Biologisches Institut II, Lehrstuhl für Biochemie der Pflanzen, Albert-Ludwigs-Universität, Freiburg i. Br., Federal Republic of Germany

    H. Grisebach

  3. Chemistry Department, The University, Glasgow, Scotland

    G. W. Kirby Sc. D. (Regius Professor of Chemistry) (Regius Professor of Chemistry)

  4. Institut für Organische Chemie, Universität Basel, Basel, Switzerland

    Ch. Tamm

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Lounasmaa, M., Galambos, J. (1989). Indole Alkaloid Production in Catharanthus roseus Cell Suspension Cultures. In: Herz, W., Grisebach, H., Kirby, G.W., Tamm, C. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 55. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9002-9_3

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