Advertisement

Subcutaneous apomorphine in Parkinson’s disease

  • C. M. H. Stibe
  • P. A. Kempster
  • A. J. Lees
  • G. M. Stern
Part of the Key Topics in Brain Research book series (KEYTOPICS)

Summary

Motor function in patients who are disabled by parkinsonian on-off oscillations can be significantly improved by administration of subcutaneous apomorphine by diurnal infusion or intermittent injection. In conjunction with use of the peripherally acting dopamine receptor antagonist domperidone, this treatment is well tolerated and has produced prolonged benefit in patients suffering from the most intractable complication of prolonged L-dopa therapy.

Keywords

Motor Response Dopamine Receptor Agonist Intermittent Injection Dyskinetic Movement Subcutaneous Apomorphine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Corsini GU, Del Zompo M, Gessa GL, Mangoni A (1979) Therapeutic efficacy of apomorphine combined with an extracerebral inhibitor of dopamine receptors in Parkinson’s disease. Lancet i: 954–956Google Scholar
  2. Cotzias GC, Papavassilou PS, Fehling C, Kaufman B, Mena I (1970) Similarities between neurological effects of L-dopa and apomorphine. N Engl J Med 282: 31–33PubMedCrossRefGoogle Scholar
  3. Critchley P, Perez F, Quinn N, Coleman R, Parkes D, Marsden CD (1986). Psychosis and the lisuride pump. Lancet ii: 349Google Scholar
  4. Kempster PA, Lees AJ, Crichton P, Frankel JP, Shorvon P (1988) Off period belching due to a reversible disturbance of oesophageal motility in Parkinson’s disease and its treatment with apomorphine. Movement Disorders (in press)Google Scholar
  5. Quinn N, Parkes JD, Marsden CD (1984). Control of the on/off phenomenon by intravenous infusion of L-dopa. Neurology 34: 1131–1136PubMedGoogle Scholar
  6. Stibe CMH, Lees AJ, Stern GM (1987) Subcutaneous infusion of apomorphine and lisuride in the treatment of parkinsonian on-off oscillations. Lancet is 871Google Scholar
  7. Stibe CMH, Lees AJ, Kempster PA, Stern GM (1988) Subcutaneous apo- morphine in parkinsonian on-off oscillations. Lancet ii 403–406CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1989

Authors and Affiliations

  • C. M. H. Stibe
    • 1
  • P. A. Kempster
    • 1
  • A. J. Lees
    • 1
  • G. M. Stern
    • 1
  1. 1.Department of Neurology, Faculty of Clinical SciencesMiddlesex and University College HospitalsLondonUK

Personalised recommendations