Sensory and musculo-skeletal dysfunction in Parkinson’s disease—premonitory and permanent

  • M. B. Streifler
Part of the Key Topics in Brain Research book series (KEYTOPICS)


In Parkinson’s disease the impressive motor symptomatology has sidetracked attention from other important constituents, like those pertaining to psycho-mental, autonomous and sensory systems. Pain and dysesthesias are present in about 60% of parkinsonians and predate the overt disease in about 20%.

Predominantly of neurogenic, “primary” origin they express a disorderly processing along central sensory pathways, a defective activity of dopaminergic and other transmitter-mediator systems.

Changes affecting musculo-skelettal structures contribute a somatic, “secondary” contingent of sensory discomfort and may determine the outward appearance of the patient.


Essential Tremor Sensory Symptom Sensory Complaint Sensory Discomfort Basal Ganglion Motor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Appenzeller O, Gross _J (1971) Autonomic deficits in Parkinson’s syndrome. Arch Neurol 24: 50 – 57Google Scholar
  2. Bowen F, Hoehn M, Yahr DM (1972) Cerebral dominance in patients with parkinsonism. Neurology 22: 32 – 39PubMedGoogle Scholar
  3. Burke D (1986) Rigidity/dystonia. Triangle 25 [Suppl 1]: 13 (and personal communication)Google Scholar
  4. Charcot JM (1877) Lectures on diseases of the nervous system, vol 1 (translated by Sigerson G). The New Sydenham Society, London, p 137 (cited ex 10)Google Scholar
  5. Della Sala S, Franchignoni FP; Grioni G, Mazzini L (1987) Scoliosis in Parkinson’s disease (PD): a reappraisal. In: Proceedings of the international symposium on parkinsonism and aging, Milan, p 41Google Scholar
  6. Dinnekstein A, Lowenthal M, Blake G (1964) Tactile delay in parkinsonism.J Nery Ment Dis 139: 521 – 524Google Scholar
  7. Ekbom K (1960) Restless legs syndrome. Neurology 10: 868 – 873PubMedGoogle Scholar
  8. Goetz CG, Tanner CM, Wilson RS, Garron DC (1986) Pain in Parkinson’s disease. Movement Disorders 1: 45 – 49PubMedCrossRefGoogle Scholar
  9. Koller WC (1984) Sensory symptoms in Parkinson’s disease. Neurology 34: 957 – 959PubMedGoogle Scholar
  10. Krauthamer G, Felty P, Albe-Fessard D (1967) Neurons of the medial diencephalon II. Excitation of central origin. J Neurophysiol 30: 81–97Google Scholar
  11. Matsumoto K, Rossomann F, Lin TH, Cooper IS (1963) Studies on induced exacerbation of parkinsonism rigidity. The effect of contralateral voluntary activity. J Neurol Neurosurg Psychiatr 26: 27–32Google Scholar
  12. Nutt JG, Carter JH (1984) Sensory symptoms in parkinsonism related to central dopaminergic function. Lancet ii: 456–457Google Scholar
  13. Parkinson J (1817) An Essay on the shaking palsy. Sherwood, Neely and Jones, London, pp 47 – 48Google Scholar
  14. Proctor F, Riklan M, Cooper IS, et al (1963) Somato-sensory status of parkinsonian patients before and after chemothalamotomy. Neurology 13: 906 – 912PubMedGoogle Scholar
  15. Snider SR, Fahn S, Isgreen WP, Cote LJ (1976) Primary sensory symptoms in parkinsonism. Neurology 26: 423 – 429PubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1989

Authors and Affiliations

  • M. B. Streifler
    • 1
  1. 1.Section of Neurology, Sackler Medical SchoolTel Aviv UniversityTel AvivIsrael

Personalised recommendations