Is D-1 receptor stimulation important for the anti-parkinson activity of dopamine agonists?

  • R. Markstein
  • J.-M. Vigouret
Conference paper
Part of the Key Topics in Brain Research book series (KEYTOPICS)


This overview summarises recent experimental findings suggesting that an optimal motor control in Parkinson’s disease depends on concurrent activation of D-1 and D-2 receptors. The clinical observation that a combination of bromocriptine (Parlodel; Pravidel) with L-DOPA produces better symptomatic control in Parkinson patients than either agent alone is explained as the result of a synergistic interaction between D-2 receptors activated by Parlodel and D-1 receptors activated by dopamine formed from L-DOPA.


Dopamine Receptor Dopamine Agonist Endogenous Dopamine Cerebral Glucose Utilisation Sensory Motor Cortex 


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Copyright information

© Springer-Verlag/Wien 1989

Authors and Affiliations

  • R. Markstein
    • 1
  • J.-M. Vigouret
    • 1
  1. 1.Preclinical ResearchSandoz Ltd.BasleSwitzerland

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