Histochemistry of MAO subtypes in the brainstem of humans: a relation to the radical hypothesis of Parkinson’s disease?

  • C. Konradi
  • P. Riederer
  • H. Heinsen
Part of the Key Topics in Brain Research book series (KEYTOPICS)


The distribution of monoamine oxidase subtypes in the human brain-stem is described. Results are discussed in relation to the MAO-B inhibiting therapy of Parkinson’s disease (PD). Additionally, attention is focused onto the pathogenesis of PD, especially on radical mechanisms which might be mediated via exotoxins and amplified by endogenous radicals.


Monoamine Oxidase Parkinsonian Patient Radical Hypothesis Endogenous Radical Neurotoxin MPTP 


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Copyright information

© Springer-Verlag/Wien 1989

Authors and Affiliations

  • C. Konradi
    • 1
  • P. Riederer
    • 1
  • H. Heinsen
    • 1
  1. 1.Clinical Neurochemistry and Morphological Brain Research, Department of PsychiatryUniversity of WürzburgFederal Republic of Germany

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