Histochemistry of MAO subtypes in the brainstem of humans: a relation to the radical hypothesis of Parkinson’s disease?
The distribution of monoamine oxidase subtypes in the human brain-stem is described. Results are discussed in relation to the MAO-B inhibiting therapy of Parkinson’s disease (PD). Additionally, attention is focused onto the pathogenesis of PD, especially on radical mechanisms which might be mediated via exotoxins and amplified by endogenous radicals.
KeywordsMonoamine Oxidase Parkinsonian Patient Radical Hypothesis Endogenous Radical Neurotoxin MPTP
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