Aspartate, glutamate, and glutamine in platelets of patients with Parkinson’s disease
Aspartate, glutamate and glutamine were determined in platelets of 29 patients with Parkinson’s disease (PD) and the results were compared with those of an age matched control group consisting of 24 healthy persons (group A). According to the predominant clinical symptomatology the patients with PD were divided into three groups: group B = patients with tremor (n = 12), group C = patients with akinesia without “on/off” phenomena (n = 11), and group D = patients with akinesia with “on/off” phenomena (n = 6).
Significant decreases of all investigated amino compounds were observed in all groups of patients with PD in comparison with the control group. In addition, aspartate and glutamate were found to be significantly decreased in the group with akinesia and with “on/off” phenomena as compared with the tremor-group. Aspartate was also significantly decreased in patients with akinesia without “on/off” phenomena as compared with the patients with tremor. Glutamine was found to be significantly different between the akinesia groups without and with “on/off” phenomena.
The results point out that platelet aspartate, glutamate and glutamine are significantly decreased in Parkinsonian patients and that there is a correlation between severity of PD and the degree of decreases of the investigated amino compounds.
KeywordsAmyotrophic Lateral Sclerosis Parkinsonian Patient Amino Compound Amino Acid Neurotransmitter High Performance Liquid Chromato
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- Berl S, Nicklas WJ (1976) Metabolism of glutamate and related amino acids in brain: effect of drugs that alter catecholamine metabolism. In: Birkmayer W, Hornykiewicz O (eds) Advances in parkinsonism. Editiones Roche, Basel, pp 193–204Google Scholar
- Gordon JL, Milner AJ (1976) Blood platelets as multifunctional cells. In: Gordon JL (ed) Platelets in biology and pathology. North-Holland, Amsterdam, pp 11–21Google Scholar
- Hassler R (1966) Thalamus regulation of muscle tone and the speed of movements. In: Purpura DP, Yahr MD (eds) The thalamus. Columbia University Press, New York, pp 418–438Google Scholar
- Hassler R, Nitsch C, Lee HL (1980) The role of eight putative transmitters in the nine types of synapses in rat caudate-putamen. In: Rinne UK, Klingler M, Stamm G (eds) Parkinson’s disease—current progress, problems and management. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 61–91Google Scholar
- Ludolph AC, Rolf LH (1988) Unpublished observationsGoogle Scholar
- Olney JW, Ho OL, Rhee V (1971) Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system. Exper Brain Res 14: 61–76Google Scholar
- Riederer P, Jellinger K (1983) Morphologie und Pathobiochemie der Parkinson-Krankheit In: Gänshirt (Hrsg) Pathophysiologie, Klinik und Therapie des Parkinsonismus. Editiones Roche, Basel, S 31–50Google Scholar
- Rolf LH, Schlake HP, Brune GG (1983) Plasmafaktoren und Migräne. In: Soyka D (Hrsg) Migräne: Pathogenese–Pharmakologie–Therapie. Enke, Stuttgart, S 79–97Google Scholar
- Spencer PS, Hugon J, Ludolph A, Nunn PB, Ross SM, Roy DN, Schaumburg HH (1987) Discovery and partial characterization of primate motor-system toxins. In: Ciba Foundation Symposium 126; Selective neuronal death. Wiley, Chichester, pp 221–237Google Scholar