Platelet MAO-B activity in humans and stumptail monkeys: in vivo effects of the reversible MAO-B inhibitor Ro 19-6327
MAO activity in platelets of six different animal species was compared with that of healthy volunteers. Only stumptail monkey (macaca arctoides) have similar high MAO-B and corresponding extremely low MAO-A activity in platelets as man. The highly selective, reversible inhibitor of MAO-B, Ro 19-6327, produced a marked and short-lasting inhibition of MAO-B in platelets of healthy volunteers as well as of stumptail monkey after oral administration. Therefore, platelets from stumptail monkey can adequately replace human platelets as model for the study of the pharmacological characteristics of MAO-B inhibitors.
KeywordsPlatelet Rich Plasma Human Platelet Washed Platelet Macaca Arctoides Stumptail Monkey
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