The diagnostic relevance of Lewy bodies and other inclusions in Parkinson’s disease
Seventy-four of 78 patients with Parkinson’s disease (PD) had Lewy bodies in the substantia nigra. Two without Lewy bodies had striatonigral degeneration and two had post-encephalitic pathology. Lewy bodies in controls occurred in 3.6% to 11.1% between the sixth and tenth decades, and similar figures were obtained in other common parkinsonian disorders and Alzheimer’s disease. Lewy bodies can also occur in corticobasal degeneration and Hallervorden-Spatz disease. The pathological diagnosis of PD depends on finding Lewy bodies in the substantia nigra, but other parkinsonian disorders must be excluded.
KeywordsSubstantia Nigra Multiple System Atrophy Lewy Body Lewy Body Disease Corticobasal Degeneration
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